Peter Attia· MD
there was a drug you taught me about a few years ago an esoteric drug that inhibited delta 24 desaturates that drug lowered cholesterol was naming that drug again try paranal try Paran also try Paran all come on since that 24 carbon and it didn't allow you to saturate it did not allow you to turn this master all into cholesterol and so now that's at the very bottom of this pathway and ultimately an ultimate molecule into the ultimate step and all of a sudden you inhibited that with this drug cholesterol levels went down FDA you really go up does master all astral and there was at least a congenital disease called desmos Colossus maybe that I don't know if they even know about that though back then we know about it now that maybe would have been a flag that when you look at so if I recall correctly about three or four years after this drug was approved because this is an era when you could approve a drug just by showing it lowered cholesterol the drug was pulled off the market and atherosclerosis was occurring cataracts were occurring red blood I think and it turns out des mas role turns out to have other roles in divides a potent cell membrane signaling molecule involved with inflammatory pathway so god knows what else you're doing by perturbing des master all levels in cells and stuff you know so you live and learn