A drug that inhibited the conversion of desmosterol to cholesterol, by inhibiting delta-6 desaturase, lowered cholesterol but increased cardiovascular events, presumably because desmosterol accumulated and acted as an oxidizing sterol.

“one of the first drugs ever approved to lower ldl did so but did not reduce events i'm blanking on the name of the drug but it actually was a drug that inhibited the enzyme that converted desmosterol to cholesterol i think it's something called delta 60 saturates or something and in doing so it did lower cholesterol and by extension ldl cholesterol although frankly at the time they probably only looked at total cholesterol but events actually went up presumably because desmosterol went up so much and acted as a sterol that had the same oxidizing properties”