Lp(a) influences the initiation of aortic valve stenosis by binding to hydroxyapatite.

“a hazard ratio of two we're gonna have three even four on aortic stenosis as I said it probably explains about two-thirds of the total volume of aortic stenosis”

“the sodium fluoride will actually bind to a chemical called hydroxy apatite which is uh literally the a complex of calcium and phosphorus which will eventually be involved in the pathophysiology of of aortic valve stenosis and we see that process happening very early at the earliest stage of the of the disease”

“wouldn't be able to gain residence in the tissues such as the sub-endothelial space the interstitial space of the aortic valve all the places where it wreaks havoc”

“the data that's available so far that have looked at the progression rates of aortic valve stenosis has shown that patients with high lpa might even progress more rapidly than patients with uh who have uh who have low lpa especially within in younger patients”

“and we also see an effect of lpa on the later stage of the disease so the the data that's available so far that have looked at the progression rates of aortic valve stenosis has shown that patients with high lpa might even progress more rapidly than patients with who have who have”

“but when you're going into and you look at patients that have very high lpa the risk can can increase quite quite substantially”

“just to remind our audience lpa is also associated to a very significant extent to aortic valve stenosis”

“so uh so lpa is probably an initiator of uh aortic valve stenosis and we've known that uh since 2013 when uh george chana sulis and and when the post uh they they published this genome-wide association studies of aortic valve calcification in the charge consortium and they've shown that lpa the with that one variant associated with high lpa level was the most important variant associated with aortic valve disease”

“and how much does it depend on whether or not they have a normal aortic valve to begin with which has three leaflets a so-called tricuspid valve versus if they have a relatively common anatomic variant with only two leaflets which is called a bicuspid valve which even outside of lp little a would increase your risk for stenosis”