Paul Saladino· MD
if we see those people like now yourself who might have an ldl of 500 that actually is at the bottom range of something known as homozygous familial hypercholesterolemia and unfortunately for those who have the genetic disease for familial hypercholesterolemia especially homozygous children as young as say two or three will often exhibit common signs of early cardiovascular disease this is part of why they believe that high ldl is independently causal because unfortunately these children even as early as age two or three may for example show tendons xanthomas tendon xanthomas are fatty deposits that'll actually appear on say your ankles or your wrists and hands or your elbows and so on and so forth