Endothelial dysfunction is a critical early step in the development of atherosclerosis, and LDL becomes problematic only in the presence of endothelial dysfunction.

“and i believe that one of the key mechanisms by which that insulin resistance may be leading to atherosclerosis is by causing endothelial dysfunction endothelial dysfunction is really probably the first or second effect the first or second really step in the process of atherosclerosis i believe you must have endothelial dysfunction to have and to have atherosclerosis without endothelial dysfunction i believe that ldl is not a problem for humans at all”