Paul Saladino· MD
you get sharp pointy blood cells hammering through your bloodstream stripping off the endothelium and you know one of the things that happens in sickle cell disease is you're gonna be a large spleen because the spleen is where red blood cells are removed and if you've got sickle-cell diseases we could turn over but quite often they can be damaged because they're so large and if you take them out and look at the arteries and the spleens they're full of atherosclerosis so here we have almost a perfect example we have one thing no other risk factors nothing else going on just damage to the endothelium and you have extreme and severe atherosclerosis at very young ages