Individuals with glycogen storage disease 1a have elevated LDL levels but not elevated atherosclerosis.

“my favorite example being glycogen storage disease glycogen sorce disease became extremely relevant to me because hey what is it that I'm positing is going on with people on a low carb diet well they have less glucose getting back to metabolism right therefore less gly glycogen stores if you have less glycogen stores your body detects that and then mobilizes more fatty acids to be fueled by what if your body has a disease where it thinks oh it's not even just that it thinks it literally does have less glycogen stores but therefore gets the signal over and over again to mobilize more fat well that's glycogen storage disease so they have higher triglycerides and they have higher abob containing lipoproteins but you know what they don't have higher levels of they don't have higher levels of atheroslerosis in spite of having the higher be and so there are now four studies that I found at least that were looking at glycogen stor disease yeah 1 a for example and it's not associated with premature atherosclerosis”

“there's a condition called glycogen storage disease 1a i think it's mongerkey's disease where people have elevated levels of ldl but they don't have elevated levels of atherosclerosis okay so what's going on there”