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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Why high LDL cholesterol does not indicate metabolic dysfunction — Whalespan

Content›Video›Why high LDL cholesterol doe…

Why high LDL cholesterol does not indicate metabolic dysfunction

Paul Saladino8m · 2022-04-11

Claims Made

16

Claims Supported

11

Support Rate

69%

Support rate

11 of 16 claims supported

11 supported5 partial / not

Claims from this content

14

✓Well SupportedA fasting insulin level below 5 micro IU/mL is considered healthy.✕Not SupportedMetabolic health context is crucial for understanding atherosclerosis, not just LDL's direct injury to the endothelium.✓Well SupportedAtherosclerosis does not develop in veins, suggesting that endothelial damage is necessary for its initiation.✕Not SupportedThe reference range for fasting insulin, which extends up to 22-26 micro IU/mL, is too high and doctors do not flag levels within this range as problematic.Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Oxidized phospholipids on ApoB provide a better assessment of oxidized LDL than traditional oxidized LDL tests.

✓Well SupportedStratifying Framingham study data by HDL cholesterol reveals a different relationship between LDL and cardiovascular disease risk compared to analyzing LDL alone.

✕Not SupportedThe number of LDL particles in circulation does not fully explain atherosclerosis.

✕Not SupportedAtherosclerosis begins with damage to the endothelium lining blood vessels.

✓Well SupportedMetabolic health determines the atherogenicity of one's lipid profile.

✓Well SupportedHigh-sensitivity C-reactive protein (hs-CRP) and fibrinogen are easily obtainable inflammatory markers.

◐Partially SupportedIndividuals with glycogen storage disease 1a have elevated LDL levels but not elevated atherosclerosis.

◐Partially SupportedFamilial Dunnigan hyperlipodystrophy is linked to a mutation causing insulin resistance and accelerated atherosclerosis.

✓Well SupportedIndividuals with familial hypercholesterolemia and lifelong LDL levels of 400-600 mg/dL can have zero atherosclerosis, suggesting LDL is not the sole cause.

◐Partially SupportedThe role of LDL in atherosclerosis is nuanced, with oxidation of LDL being a key factor.