Metabolic health context is crucial for understanding atherosclerosis, not just LDL's direct injury to the endothelium.

“people generally people who espouse the lipid hypothesis point to the FH trials and what I'm trying to bring up here with data is to highlight the idea when you're pointing to the familial hypercholesterolemia trials we have to be very careful of the details”

“the lipid hypothesis as described right now it's sort of difficult for me to follow through and I think while the response to injury hypothesis or chronic endothelial injury hypothesis just makes a lot more sense the more I've been getting into it”

“there are very clear dissenting evidence that LDL yeah I would say it is far from proven that LDL molecules are directly toxic to the endothelium so”

“neither you nor I believe that LDL itself can damage the endothelium and that is exactly what the LDL hypothesis rests upon right if if we cannot show and I do not believe there's any evidence in the literature in medicine today to definitively show that LDL damages the endothelium then the entire LDL hypothesis falls apart right there immediately right”

“if we cannot show and I do not believe there's any evidence in the literature in medicine today to definitively show that LDL damages the endothelium then the entire LDL hypothesis falls apart right there immediately”

“there's lipid battles and and there's this huge bias in lipids everybody everybody's seeing things through the lens of ldl being directly pathogenic to the endothelium”

“there's this huge bias in lipids everybody everybody's seeing things through the lens of ldl being directly pathogenic to the endothelium”

“I'm not sure how someone is going to make an argument that LDL is directly injurious to the endothelium with data like this in existence and I'm not sure how you can make an argument that the response to retention hypothesis is complete or should be the prevailing Paradigm for atherosclerosis”

“i don't think ldl particles are directly atherogenic to the human endothelium that doesn't make sense to me and i don't think there's enough data to support that now again deep rabbit hole i'll just hit a couple highlights here there's definitely case studies of people with familial hypercholesterolemia four to six hundred for their whole life with zero atherosclerosis”

“i believe the answer is no but many would disagree with me and we need many more of those debates i think there's a lot of good evidence that that particle has not been indicted fully see that particle's definitely causing atherosclerosis it gets involved but is it a fireman or the arsons right just because it shows up at the fire doesn't mean it's actually causing the fire”

“i have shown you that there is very little i would say no solid evidence that ldl is directly injurious to cell membranes and i would say that there is in fact no evidence that ldl is directly injurious to the endothelium the inner layer of blood vessels”

“and i believe that is the oversight that is made by physicians in the medical community over and over and over if you repeat a lie often enough it becomes the truth”

“i do not believe for one second that there is enough evidence to say confidently and i believe there's a lot of evidence to the contrary that ldl moving into arterial walls is a concentration-based effect or that ldl is directly toxic to the endothelium i don't think those have ever been shown clearly in the medical literature”

“I think there is a enormous amount of evidence calling into question the notion that LDL or apob containing particles are directly injurious to the endothelium”