Why I don't worry about my cholesterol

PS

Paul Saladino56m · 2022-06-21

Claims Made

103

Claims Supported

79

Support Rate

77%

Support rate

79 of 103 claims supported

79 supported24 partial / not

Claims from this content

80

Well SupportedInsulin resistance makes LDL 'stickier,' increasing cardiac risk, while individuals who are insulin sensitive show no increase in cardiac risk with higher LDL levels.Well SupportedMetabolic dysfunction, specifically insulin resistance, is the primary event leading to atherosclerosis, not LDL directly injuring the endothelium.Well SupportedFasting insulin levels, ideally below 5 and preferably below 3, are crucial for assessing insulin sensitivity.Well SupportedAn animal-based diet of well-raised meat, organs, and low-toxicity plant foods is believed to be powerfully beneficial.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well Supported

When Framingham data is not stratified by metrics associated with insulin resistance, LDL cholesterol shows a linear correlation with cardiovascular disease incidence.

Not SupportedMetabolic health context is crucial for understanding atherosclerosis, not just LDL's direct injury to the endothelium.

Well SupportedA basic lipid panel with apolipoprotein B (apoB) is sufficient for assessment when interpreted in the context of insulin sensitivity and fasting insulin levels.

Well SupportedAtherosclerosis does not develop in veins, suggesting that endothelial damage is necessary for its initiation.

Well SupportedFamilial partial lipodystrophy caused by LMNA mutations leads to insulin resistance and early coronary heart disease.

Well SupportedImpaired wound healing at the endothelial level in individuals with insulin resistance prevents proper repair, leading to the initiation of atherosclerosis.

Well SupportedElevated Lp(a) and elevated oxidized phospholipids on apoB is of greater concern than elevated Lp(a) with normal oxidized phospholipids on apoB.

Well SupportedSaturated fat might be a normal adaptive response to maintain cell membrane fluidity, even if it raises LDL cholesterol.

Well SupportedLDL particles perform beneficial functions such as immunological function and cell membrane formation.

Not SupportedLowering LDL cholesterol independently of insulin sensitivity metrics is not a reliable indicator for cardiovascular disease prevention or prediction.

Well SupportedIncreasing saturated fat and decreasing monounsaturated and polyunsaturated fats in the diet leads to higher LDL cholesterol for approximately 70% of people.

Well SupportedCholesterol is essential for cell membrane structure and is a substrate for vital hormone production.

Well SupportedPaul Saladino has a coronary artery calcium scan of zero.

Well SupportedMinimizing or eliminating seed oils from the diet improves overall health and can positively impact various bodily functions.

Well SupportedLDL particles can bind to and neutralize lipopolysaccharide, lipotichoic acid, and viruses, playing an essential role in the innate immune system.

Well SupportedClinically meaningful atherosclerosis in humans is dependent on insulin resistance, barring rare genetic conditions.

Well SupportedHyperinsulinemia is an independent risk factor for ischemic heart disease.

Well SupportedFruit is favored as a carbohydrate source because it is easily digestible and contains very few plant defense chemicals.

Partially SupportedChildren with Smith-Lemli-Opitz syndrome exhibit developmental abnormalities due to deficits in LDL particles and lack of cholesterol production.

Well SupportedExposure to UVA light increases nitric oxide production in skin cells for up to 48 hours, benefiting blood vessel health.

Well SupportedThe Boston Heart oxidized phospholipid assay quantifies oxidized phospholipids on ApoB-containing lipoproteins per unit of blood.

Well SupportedPeople with familial lipodystrophy develop significant atherosclerosis despite not having elevated LDL levels.

Well SupportedMaintaining insulin sensitivity can mitigate artery damage, and LDL may be involved in the atherosclerotic process in damaged arteries but does not initiate it.

Well SupportedA high LDL cholesterol level may not always be detrimental, particularly for individuals who are insulin sensitive.

Partially SupportedHyperinsulinemia is an independent risk factor for ischemic heart disease, predicting it better than LDL cholesterol.

Partially SupportedLDL cholesterol has important roles in immune function, quorum sensing, delivering fat-soluble vitamins and coenzyme Q10, and as cellular membrane components.

Not SupportedIncreasing polyunsaturated fat intake while decreasing saturated fat intake can lead to an increase in oxidized LDL and lipoprotein(a).

Partially SupportedReversing insulin resistance to improve health involves eliminating seed oils and processed sugars, and consuming nutrient-rich foods like meat and saturated fats.

Partially SupportedDietary fat is packaged into triglycerides in the gut and then into chylomicron particles for transport in the bloodstream.

Partially SupportedFish consumption is associated with increased rates of melanoma due to potential contamination.

Partially SupportedHigher fish intake, tuna intake, and non-fried fish intake are positively associated with the risk of melanoma.

Partially SupportedCholesterol supplementation with egg yolks and bile acids can improve growth, reduce photosensitivity, and ameliorate severe infections in individuals with Smith-Lemli-Opitz syndrome without harmful side effects.

Partially SupportedUV light and fermented foods increase gut microbial diversity.

Partially SupportedAn animal-based diet using Heart & Soil organs and supplements for seven months led to thriving.

Partially SupportedLDL may be directly injurious to cell membranes, act as an innocent bystander, or protect damaged cell membranes.

Partially SupportedInsulin resistance is the primary cause of arterial stickiness and the initial event in atherosclerosis.

Partially SupportedChylomicron remnants are taken up by the liver, which then synthesizes and releases LDL as a transport vehicle.

Partially SupportedLDL and apob are not directly atherogenic, though LDL may be involved in arterial healing and its movement into the sub-endothelial space might be an active process.

Partially SupportedFeeding an eight-month-old son fruit and organ meats as first foods has resulted in him thriving.

Partially SupportedEliminating seed oils may lead to radical health improvements for autoimmune issues.

Partially SupportedEliminating processed sugars and seed oils while focusing on beef and fruit will lead to improved insulin sensitivity.

Partially SupportedA healthy endothelium is indicated by insulin sensitivity, an HDL triglyceride ratio, or the absence of arterial plaque visible in the back of the eye.

Partially SupportedA slight increase in LDL cholesterol from saturated fat intake is acceptable and potentially beneficial in insulin-sensitive individuals.

Partially SupportedChimpanzees with high LDL and ApoB similar to humans do not develop atherosclerosis, suggesting LDL itself is not the direct cause.

Partially SupportedPediatric patients with glycogen storage disease types 1a and 3 do not develop atherosclerosis, despite dyslipidemia, because they are not insulin resistant.

Partially SupportedLDL cholesterol does not directly damage the endothelium, challenging the 'response to injury' hypothesis.

Partially SupportedLipoproteins, including LDL, are essential for life and transport cholesterol needed for cell membranes.

Partially SupportedCell membranes maintain constant fluidity by inserting cholesterol molecules.

Partially SupportedConsuming seed oils high in polyunsaturated fatty acids generally lowers LDL cholesterol.

Partially SupportedApolipoprotein B is critical for LDL particles to be taken into the cell membrane, initiating atheroma formation.

Partially SupportedLP-PLA2 tracks with LDL and is not a superior cardiovascular risk marker on its own.

Partially SupportedCirculating lipoproteins may serve as a buffer to enable rapid redistribution of cholesterol molecules between cells and tissues in response to changes in dietary fat supply, helping to maintain cell membrane fluidity.

Partially SupportedEndothelial health can be supported by sunlight exposure, which elevates nitric oxide.

Partially SupportedCoenzyme Q10 is a critical component made from downstream products of mevalonate and is prevalent in heart tissue.

Partially SupportedThe correlation between meat consumption and heart disease in the American population is likely due to the simultaneous consumption of seed oils and processed sugars, rather than the meat itself.

Partially SupportedChylomicron remnants and free fatty acids are taken up by the liver, with insulin playing a role in this process.

Partially SupportedHeart & Soil's Skin, Hair, and Nails supplement improved postpartum hair loss and milk production.

Partially SupportedLDL particle number (LDLp) and apob-containing lipoproteins are essentially the same as LDL measured in milligrams per deciliter and increase with saturated fat intake.

Partially SupportedLDL is essential for life, as shown by Smith-Lemli-Opitz syndrome where insufficient LDL leads to severe health consequences.

Partially SupportedLipoprotein lipase acts on chylomicrons, facilitating cholesterol ester and triglyceride transfer between remnants and HDL via CETP.

Partially SupportedA 2005 study found no association between LDL levels and atherosclerosis via coronary artery calcium scores.

Partially SupportedThe benefits of UVA light on skin, such as increased nitric oxide, cannot be replicated by a vitamin D pill.

Partially SupportedReversing autoimmune disease has been achieved through an animal-based lifestyle and organ nutrition.

Not SupportedThe belief that the sun is harmful is an incomplete truth or lie that should be questioned.

Not SupportedFamilial hypercholesterolemia (FH) is a poor model for studying hyperlipidemia's role in atherosclerosis because mutations can affect immune cells involved in plaque formation, not just LDL levels.

Partially SupportedLow HDL can occur in individuals who are not insulin resistant, particularly if they cycle through HDL more quickly.

Partially SupportedLDL particles drop off cholesterol at cells to maintain cell membrane fluidity.

Partially SupportedInsulin stops the flow of free fatty acids into the bloodstream.

Partially SupportedAn animal-based diet excluding supplements and focusing on organ meats led to significant improvements in postpartum hair loss and milk production.

Partially SupportedCholesterol from red meat is beneficial for cell membranes, immune response, and hormone production.

Partially SupportedEPA and DHA showed a substantial protective association against melanoma.

Partially SupportedMeat and saturated fat are beneficial for health and can help resolve insulin resistance.

Partially SupportedDietary polychlorinated biphenyls (PCBs) are associated with the risk of melanoma.

Not SupportedPaul Saladino does not inhibit cholesterol production because cholesterol is essential for his hormones and overall biology.

Partially SupportedAssociations between meat and cardiovascular disease or decreased lifespan do not consistently occur across all studied populations.

Partially SupportedCholesterol is critical for proper bodily function.