Paul Saladino· MD
I would posit my hypothesis would be that the initiator of atherosclerosis for many people is insulin resistance
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
I would posit my hypothesis would be that the initiator of atherosclerosis for many people is insulin resistance
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
if they're not insulin resistant they're not going to develop atherosclerosis
atheroma related atherosclerosis does not occur independent of insulin resistance
I don't think there's a significant amount of cardiovascular disease that's clinically meaningful for humans that happens independent of insulin resistance.
I don't think that clinically meaningful atherosclerosis except for maybe a few genetic conditions we can talk about those you know familial you know like like this you know like um what am I thinking about FH or done again lipodystrophy you know um but that but those people are insulin resistant as I you know by default anyway so I don't think a lot of cardiovascular disease I don't think there's a significant amount of cardiovascular disease that's clinically meaningful for humans that happens in the pendant of insulin resistance