Is atherosclerosis inevitable?

PS

Paul Saladino12m · 2022-11-23

Claims Made

32

Claims Supported

27

Support Rate

84%

Support rate

27 of 32 claims supported

27 supported5 partial / not

Claims from this content

29

Well SupportedObtaining 2.6 grams of leucine from plant-based foods like lentils or beans requires consuming nearly half a pound of these foods.Well SupportedSarcopenia is a greater threat to longevity than red meat consumption, and red meat is not detrimental to longevity.Well SupportedDiabetics and insulin-resistant individuals have impaired immunity and wound healing.Well SupportedClinically meaningful atherosclerosis in humans is dependent on insulin resistance, barring rare genetic conditions.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Exercise increases insulin sensitivity, reducing the need for insulin, and skeletal muscle is the first tissue to develop insulin resistance.

Well SupportedActivating mTOR is necessary for muscle building and maintaining muscle mass, which is important for longevity, insulin sensitivity, and avoiding sarcopenia.

Partially SupportedIndividuals with high ApoB may have varying degrees of arterial plaque, inflammation, and insulin resistance.

Well SupportedMitochondria become less effective at making energy by approximately 10% each decade after birth.

Well SupportedCGMs assess glucose disposal and identify insulin resistance when static tests are insufficient.

Well SupportedDamage to the arterial endothelium's glycocalyx allows LDL to enter the arterial wall and initiate atherosclerosis.

Partially SupportedThe Max Pulse test assesses arterial elasticity and can indicate endothelial dysfunction if arteries are stiff.

Partially SupportedThe Endopath device performs a 15-minute arterial stress test, including a 5-minute brachial artery occlusion, to assess endothelial function and nitric oxide response.

Partially SupportedHealthy arteries should be able to at least double, and ideally triple or quadruple, in size when subjected to a vessel stressor.

Partially SupportedIndividuals with a history of stents or bypass surgery can prevent subsequent cardiovascular events by improving arterial health and repairing existing plaque.

Partially SupportedThe negatively charged endothelial glycocalyx and lipoproteins repel each other, facilitating the unimpeded passage of LDL particles.

Partially SupportedTreatment for cardiovascular disease should be individualized, especially for younger individuals without a history of cardiac events.

Partially SupportedInsulin resistance is underdiagnosed when only checking hemoglobin A1c and glucose.

Well SupportedElevated LDL particle concentration is a significant risk factor for cardiovascular events over 20-30 years.

Partially SupportedThe organs with the most mitochondria, such as the brain, heart, and skeletal muscle, are primary targets for interventions supporting mitochondrial health.

Partially SupportedIndividuals with a history of heart attack, multi-vessel bypass, or high risk for a second event may benefit from aggressive therapies like statins and PCSK9 inhibitors.

Partially SupportedDilation levels of three or four on the Endopath test suggest a low current risk of developing new atherosclerotic plaque.

Not SupportedThe idea that everyone needs a statin or PCSK9 inhibitor to achieve LDL below 30-40 mg/dL or ApoB below 50 is considered 'bonkers'.

Partially SupportedLack of movement and insufficient protein intake contribute to insulin resistance, which can damage arteries.

Partially SupportedDiabetics and pre-diabetics show increased rates of atherosclerosis, likely due to impaired wound repair in arteries.

Partially SupportedIndividualized medicine is necessary for treating cardiovascular risk factors like ApoB.

Partially SupportedStatins and PCSK9 inhibitors are not universally beneficial and should not be mandatory for the general population.

Partially SupportedTreating individuals based on specific health markers, rather than population averages, is crucial because plaque formation can vary significantly even among individuals with similar ApoB levels.

Partially SupportedAddressing root causes of inflammation, such as poor gut health, thyroid disease, inadequate sleep, or excessive blue light exposure, is crucial for lowering inflammation and maintaining healthy nitric oxide levels, thereby preventing lipoprotein deposition in arteries.

Not SupportedLimiting leucine and methionine is counterproductive for muscle mass and longevity.