Paul Saladino· MD
There there is an association, I think, in the literature between higher levels of apoB particles and atherosclerosis. But the keyword there is association.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
There there is an association, I think, in the literature between higher levels of apoB particles and atherosclerosis. But the keyword there is association.
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In people who have insulin resistance, yeah, there could be some of that apoB going into the artery wall, and potentially the artery wall is damaged, because we know that wound repair, endothelial repair is probably damaged in cases of insulin resistance.
And the people like me, perhaps, but you can disagree with me if you don't agree with this hypothesis, an elevated apoB, {quote} {unquote}, may not actually be driving atherosclerosis, because hopefully I and many of people that listen to this podcast don't fall into that murky water.
if you take all comers with you know in April B of 180 well a good chunk of them are going to have you know plaque in their left interior descending and some of them won't
if you have some degree of insulin resistance you are at a higher risk of atherosclerosis not because of your elevated apob but because of the way those LDL particles those apob particles are retained in the arterial wall