I debated a cardiologist on cholesterol MUST WATCH

PS

Paul Saladino13m · 2023-09-13

Claims Made

31

Claims Supported

20

Support Rate

65%

Support rate

20 of 31 claims supported

20 supported11 partial / not

Claims from this content

28

Well SupportedInsulin resistance makes LDL 'stickier,' increasing cardiac risk, while individuals who are insulin sensitive show no increase in cardiac risk with higher LDL levels.Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.Well SupportedOxidized LDL with an oxidized ApoB100 particle is atherogenic, while native LDL is not.Well SupportedThe breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Increased linoleic acid consumption leads to accumulation in adipose tissue and LDL particles, making LDL more susceptible to oxidation.

Well SupportedAdipose tissue levels are a more accurate indicator of linoleic acid consumption than blood levels.

Well SupportedThe primary targets for cardiovascular health should be insulin resistance and the subsequent susceptibility of LDL to oxidation, rather than LDL-C itself.

Well SupportedNative LDL does not initiate atherosclerosis and will not be taken up by macrophages in the sub-endothelial space.

Well SupportedFree-living human populations exist that are free from chronic diseases such as obesity, diabetes, cardiovascular disease, autoimmunity, cancer, depression, and dementia.

Well SupportedTo establish LDL as causal, one must ensure atherogenic dyslipidemia does not affect LDL levels and no other factor causes both LDL and the outcome.

Well SupportedSoybean oil consumption increases LPPla2, a particle involved in cleaving oxidized phospholipids in LDL.

Partially SupportedIndividuals with high ApoB may have varying degrees of arterial plaque, inflammation, and insulin resistance.

Partially SupportedThe LDL molecule is essential for human life and its direct role in causing atherosclerosis is questionable, suggesting metabolic health is more significant.

Not SupportedConsuming more linoleic acid from seed oils leads to accumulation in adipose tissue and LDL particles.

Partially SupportedSaturated fat in dairy may be cardio-protective.

Partially SupportedThe amount of apob in arterial plaque does not correlate with the amount of apob in the serum.

Well SupportedLowering LDL cholesterol reduces the risk of atherosclerosis.

Partially SupportedSeed oil consumption reduced cardiovascular mortality and strokes in a study of 68,000 participants.

Partially SupportedElderly individuals (80+) with elevated LDL cholesterol tend to live the longest.

Partially SupportedLowering LDL cholesterol has been proven to lead to better health outcomes compared to not lowering it.

Partially SupportedFree-living populations with low rates of chronic disease consume meat, organs, dairy fat, honey, and sugar, and do not consume seed oils.

Partially SupportedWhen the general population is metabolically unwell, it can create confusion leading to the belief that LDL causes cardiovascular disease.

Not SupportedLinoleic acid may be the worst dietary component for cardiovascular health.

Partially SupportedIn young, healthy individuals, atherosclerosis prevalence increases with higher LDL levels.

Partially SupportedLDL cholesterol does not associate with cardiovascular disease when stratified by metrics correlating with insulin sensitivity or resistance.

Partially SupportedWhen LDL is corrected for Lp(a) levels, LDL is no longer predictive of cardiovascular disease.

Partially SupportedIncreased saturated fat intake raises LDL but decreases Lp(a) and oxidized LDL, while increased linoleic acid intake decreases LDL but increases Lp(a) and oxidized LDL.

Partially SupportedAn animal-based diet including meat and organs can lead to increased insulin sensitivity, improved metabolic health, and good nutrient intake.

I debated a cardiologist on cholesterol *MUST WATCH*

I debated a cardiologist on cholesterol MUST WATCH