Paul Saladino· MD
Furthermore, data regarding increases in oxLDL and Lp(a) with increased polyunsaturated and decreased saturated fat have largely been ignored because they don't fit the prevailing narrative.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Furthermore, data regarding increases in oxLDL and Lp(a) with increased polyunsaturated and decreased saturated fat have largely been ignored because they don't fit the prevailing narrative.
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Less SF and more PUFA increased plasma concentrations of lipoprotein(a) and OxLDL-EO6.
Less SF and more PUFA increased plasma concentrations of lipoprotein(a) and OxLDL-EO6.
Less SF and more PUFA increased plasma concentrations of lipoprotein(a) and OxLDL-EO6.
How to increase oxidized LDL and Lp(a): also adding more polyunsaturated fats to your diet.
it's pretty clear that if you stuff more linoleic acid into your body then you're going to get more oxidized phospholipids and more lp little a
in that first study I showed when you introduce more polyunsaturated fats into your diet LP little a goes up oxidized LDL goes up so your LDL is probably protecting you
if you decrease saturated fat and increase polyunsaturated fat your lp little a goes up your oxidized ldl goes up this is very bad
in that first study i showed when you introduce more polyunsaturated fats into your diet lp little a goes up oxidized ldl goes up
there's very good evidence that when you do that there are Interventional trials in humans showing that when you replace saturated fat with polyunsaturated fat you will lower your LDL your LDL will go down but your oxidized LDL and your LP little a which is a lipoprotein we haven't talked about but it's a cousin of LDL will go up
in contrast to low density lipoprotein something that is not strongly associated with cardiovascular disease if you actually look at the research very well ldl is a piss poor predictor of cardiovascular disease risk
eating more polyunsaturated fats may lower your LDL but will raise your LP little a and oxidize LDL
the amount of oxidized LDL in the plasma went up when you do that when you have less saturated fat and more polyunsaturated fats the oxidized LDL goes up so the median plasma oxidized LDL increased by 27 percent in response to the low fat low vegetable diet and 19 in response to the low-fat High vegetable Diet
when you do that when you have less saturated fat and more polyunsaturated fats the oxidized LDL goes up
what else do we know about more saturated fat and less polyunsaturated fat in the human diet well that type of a change while it raises LDL lowers oxidized LDL and LP little a the latter two markers are much better indicators of cardiovascular health and cardiovascular outcomes than LDL itself
what else do we know about more saturated fat and less polyunsaturated fat in the human diet well that type of a change while it raises LDL lowers oxidized LDL and LP little a the latter two markers are much better indicators of cardiovascular health and cardiovascular outcomes than LDL itself
here is a study in humans decreasing saturated fat and increasing seed oils increasing linoleic acid increases oxidized LDL and LP little a so I don't think there are any cardiologists out there who would say that increasing oxidized LDL and d and increasing LP delay is a good thing so saturated fat intake decreased polyunsaturated fat increase and they say alterations in dietary fat resulted in increased plasma concentrations of LP little a and oxidized LDL
saturated fat doesn't raise your LDL absolutely it does no question that's not what I'm saying I think that but what are you saying tell me yeah yeah that's what I'm saying like saturated fat doesn't raise your health I'm not arguing that saturated fat doesn't raise your LDL what I'm arguing is that saturated fat while it raises your LDL decreases your oxidized LDL decreases your LP little a
if you're eating saturated fat from steak or butter you're going to have more LDL but you're also going to have less LP little a and less oxidized LDL and if you eat seed oils you're going to have less LDL but I think that the Cardiology Community is missing the fact that you have increased LP little a and increase oxidized Leo
changes in dietary fat intake alter plasma levels of oxidized low density lipoprotein and LP ltil a
in fact what has been shown is that saturated fat versus polyunsaturated fat is going to lower oxidized LDL and lower LP little a which are both very strong risk factors of coronary artery disease
when you decrease the saturated fat in your diet and you increase the polyunsaturated fats from seed oils your LDL may go down but your oxidized LDL and your LP little a marker that I'll show you on my labs in a moment will go up