Does meat cause heart disease, gout and cancer?

PS

Paul Saladino12m · 2023-02-10

Claims Made

32

Claims Supported

18

Support Rate

56%

Support rate

18 of 32 claims supported

18 supported14 partial / not

Claims from this content

28

Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.Well SupportedFasting insulin levels, ideally below 5 and preferably below 3, are crucial for assessing insulin sensitivity.Well SupportedIn Eastern epidemiological studies, higher red meat consumption in men was associated with lower rates of heart disease, and in women with lower rates of breast cancer.Well SupportedA basic lipid panel with apolipoprotein B (apoB) is sufficient for assessment when interpreted in the context of insulin sensitivity and fasting insulin levels.Partially Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

The unhealthy user bias suggests that individuals who disregard mainstream health advice and consume red meat may also engage in other risky behaviors.

Not SupportedLowering LDL cholesterol independently of insulin sensitivity metrics is not a reliable indicator for cardiovascular disease prevention or prediction.

Well SupportedInsulin-resistant individuals increasing meat intake should monitor uric acid and prioritize improving insulin sensitivity by eliminating processed sugar and seed oils.

Not SupportedThe IARC WHO report on red meat and cancer is inconclusive and lacking.

Well SupportedDietary changes can improve markers of insulin sensitivity within two weeks.

Partially SupportedKetogenic diets may acutely increase cortisol and sympathetic nervous system activity, potentially normalizing over time.

Not SupportedThe vegan hypothesis that meat consumption is harmful due to raised mTOR levels, which promote cancer, is not supported by the overall evidence.

Partially SupportedBalancing mTOR activation with the AMPK pathway, achieved through fasting or low-carbohydrate consumption, is important.

Not SupportedThe relationship between diet (meat, organs, fruit) and uric acid levels is complex and not the sole determinant of gout.

Partially SupportedPaul Saladino's uric acid levels are often below 4, even when consuming large amounts of meat, organs, fruit, and fructose.

Partially SupportedGrains, seed oils, and high fructose corn syrup are causes of health problems, not red meat.

Not SupportedOver-emphasizing AMP-activated kinase (AMPK) and excessive fasting are not advisable; natural periods of mTOR inhibition, such as during sleep, are sufficient.

Not SupportedThe hypothesis that LDL is a primary driver of cardiovascular issues is greatly overblown.

Partially SupportedMeat and organs are nutrient-rich sources of nutrition.

Partially SupportedCardiologists often aim to lower LDL and ApoB as much as possible, sometimes recommending seed oils over saturated fats.

Partially SupportedIndividuals with high HDL, low triglycerides, and elevated LDL have little to no increased risk of cardiovascular disease.

Partially SupportedThe main drivers of cancer are excess lipolysis, permeability of cell membranes due to excess polyunsaturated fatty acids, and underlying insulin resistance.

Partially SupportedEating meat supports healthy bones, muscles, and ligaments, and protects against age-related muscle loss, sarcopenia, and fractures.

Partially SupportedA diet rich in meat and organs, excluding seed oils and grains, combined with good sleep, sunlight, and vitamin D, promotes insulin sensitivity and lowers cardiovascular disease risk.

Partially SupportedWeight loss alone does not equate to improved health; understanding root causes and using meaningful metrics beyond subjective feelings or simple fat measurements is crucial.

Partially SupportedImproved thyroid function and reduced iron stores may contribute to lower LDL and ApoB levels.

Partially SupportedRed meat consumption does not increase cancer risk, unlike diabetes and obesity.

Partially SupportedDrinking Glucerna may lead to increased satiety and weight loss but can also contribute to insulin resistance and metabolic unwellness, particularly if visceral fat is not monitored.

Partially SupportedObservational studies show meat consumption is associated with more cardiovascular disease in Western populations but not in Asian populations.