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Weekly · Sunday Morning

Five longevity claims.
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Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Is LDL your friend or foe? — Whalespan

Content›Video›Is LDL your friend or foe?…

Is LDL your friend or foe?

Paul Saladino5m · 2020-10-29

Claims Made

9

Claims Supported

3

Support Rate

33%

Support rate

3 of 9 claims supported

3 supported6 partial / not

Claims from this content

8

✓Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.◐Partially SupportedLDL may serve as a protective repository for oxidized phospholipids, and Lp(a) might function as a sacrificial component of this system.✓Well SupportedThe speaker's LDL cholesterol is lower now than when on a ketogenic diet or earlier in their carnivore journey due to the addition of carbohydrates.✕Not SupportedLDL's involvement in atherosclerosis is likely that of a fireman responding to a fire, not the cause of the fire itself.

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐Partially Supported

Focus on preventing oxidative injury rather than solely reducing LDL levels, as more LDL might aid in preventing and helping oxidative injury.

◐Partially SupportedElevated oxidized LDL may be a protective mechanism, sacrificing itself to shield important cells from oxidative injury, rather than being a primary cause of harm.

✕Not SupportedCardiologists recommending polyunsaturated vegetable oils may have contributed to atherosclerosis over the past 70 years.

◐Partially SupportedAtherosclerosis may be a normal vessel repair mechanism that becomes problematic when it escalates beyond the body's capacity.