Seed oils vs. saturated fat

PS

Paul Saladino27m · 2023-08-17

Claims Made

62

Claims Supported

37

Support Rate

60%

Support rate

37 of 62 claims supported

37 supported25 partial / not

Claims from this content

55

Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.Well SupportedSeed oils high in linoleic acid increase oxidized LDL and Lp(a), raising cardiovascular disease risk.Well SupportedLowering dietary linoleic acid in humans reduces the production of oxidized linoleic acid metabolites implicated in oxidative stress.Well SupportedSerum levels of linoleic acid are not a good indicator of long-term linoleic acid consumption or a predictor of adverse health events, unlike adipose tissue levels.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Soybean oil increases lipoprotein-associated phospholipase A2 (LpPLA2) in humans.

Well SupportedIncreased overall saturated fat intake generally leads to higher LDL levels, although some saturated fats like stearic acid may not.

Well SupportedSubcutaneous adipose tissue linoleic acid levels correlate with cardiovascular disease incidence.

Well SupportedThere is little evidence to support the relationship between saturated fatty acids and higher heart disease risk.

Not SupportedAvoiding seed oils is crucial for health because their linoleic acid content is prone to oxidation, creating oxidative stress.

Not SupportedConsuming more linoleic acid from seed oils leads to accumulation in adipose tissue and LDL particles.

Well SupportedIncreased consumption of linoleic acid leads to increased levels of breakdown products like 4-HNE and 9- and 13-HODEs.

Well SupportedA large study with 76,000 fatty acid measurements concluded that switching from saturated fat to seed oils, specifically linoleic acid, is cardio protective.

Well SupportedThere is a consistent correlation between linoleic acid consumption and macular degeneration in observational studies.

Partially SupportedPaul Saladino recommends fresh, cold-pressed extra virgin olive oil to his patients.

Partially SupportedChronic diseases like diabetes and insulin resistance are more common in Western societies than in indigenous cultures.

Partially SupportedLinoleic acid in the blood is an inaccurate measure of consumption and can be metabolized into other compounds.

Partially SupportedStudies on saturated fat can be confounded by healthy user bias and unhealthy user bias.

Partially SupportedSaturated fat is beneficial for health and is something humans have historically craved.

Well SupportedButter consumption is associated with cardiovascular risk.

Partially SupportedAdipose tissue linoleic acid is the accurate measure of linoleic acid's impact on cardiovascular disease.

Partially SupportedPopulations like the Kitavan people and Polynesian Islanders consume high amounts of saturated fat with no evidence of vascular disease.

Partially SupportedSaturated fat in dairy may be cardio-protective.

Partially SupportedReducing saturated fat intake from 30% to 12% of total calories did not significantly decrease cardiovascular mortality or disease in one study.

Partially SupportedInterventional animal models investigating fat effects differ from human epidemiology due to confounding biases.

Partially SupportedSubstituting butter with any unsaturated fat leads to improved outcomes.

Partially SupportedLinoleic acid has been shown to reduce total cholesterol and LDL, especially when substituted for saturated fat.

Partially SupportedSome populations, like those in America and Europe, may not have the genetic ability to process saturated fat in the same way as isolated, evolved societies.

Partially SupportedIndigenous diets often include meat, organs, dairy fat, honey, and sugar, while excluding seed oils.

Partially SupportedThe pervasive presence of seed oils in the modern diet correlates with a decline in men's testosterone levels.

Partially SupportedHigher linoleic acid content in breast milk is negatively correlated with motor and cognitive skills in children.

Partially SupportedSeed oil consumption reduced cardiovascular mortality and strokes in a study of 68,000 participants.

Partially SupportedAtherosclerosis originates in the sub-endothelial space where macrophages initiate foam cell formation.

Partially SupportedOlive oil and butter are recommended cooking fats.

Partially SupportedStudies including adipose tissue linoleic acid measurements found no correlation or protective benefit of linoleic acid for cardiovascular disease.

Not SupportedMany studies linking higher serum linoleic acid to negative outcomes are small and use inaccurate measurements.

Not SupportedLinoleic acid may be detrimental to cardiovascular health by increasing LDL oxidation and Lp(a), and negatively impacting male hormones and children's health.

Not SupportedLDL enriched in linoleic acid is more likely to be oxidized in the sub-endothelial space.

Partially SupportedForty percent of observed mortality reduction was attributed to reduced saturated fat intake, and 20% to reduced blood pressure.

Not SupportedUsing statistical analysis to determine the relative impact of multiple interventions in a single study can be misleading.

Not SupportedHigh levels of linoleic acid in colostrum are associated with poor child development at two and three years of age.

Not SupportedIncreased linoleic acid intake from seed oils is associated with decreases in male sex hormones in healthy men.

Not SupportedSerum linoleic acid measurements are inaccurate and do not reflect actual linoleic acid consumption.

Not SupportedThe relationship between saturated fat intake and cardiovascular disease is not a straight line.

Partially SupportedStudies can be designed to show no negative effects from reducing or increasing saturated fat intake.

Partially SupportedCardiovascular risks increase significantly above approximately 8% saturated fat intake up to about 10%, after which the risk plateaus.

Partially SupportedThe American Heart Association's recommendation that saturated fat intake below 6.5% of total calories is most protective against cardiovascular outcomes is a valid perspective.

Partially SupportedCardiovascular deaths have decreased by 60% since the 1960s, coinciding with increased seed oil consumption.

Not SupportedThe Western Medical system may be missing the mark by using serum linoleic acid as a marker, when adipose tissue linoleic acid is required.

Not SupportedThe totality of evidence regarding saturated fat is misleading and requires examination of confounding factors like healthy user bias.

Partially SupportedFree-living populations, such as the Hadza, consume high amounts of saturated fat and dairy without significant cardiovascular disease.

Partially SupportedHigher serum linoleic acid is associated with increased oxidized LDL, increased Lp(a), worse child development, and worse male hormone levels.

Partially SupportedFor the past 70 years, healthy individuals have avoided saturated fat, while unhealthy individuals have consumed it along with other unhealthy behaviors.

Partially SupportedA meta-analysis of butter consumption risk involved nine databases and 6.5 million person-years, not nine participants.

Partially SupportedA public health intervention in North Karelia, Finland, reduced saturated fat intake and blood pressure, resulting in an 84% reduction in overall mortality over two decades.

Partially SupportedElevated serum linoleic acid may indicate a lack of inflammation.