Paul Saladino· MD
We’ve known for a while that as seed oils lower LDL, they also RAISE oxidized LDL and Lp(a). (PMID: 8432867, 28503188)
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We’ve known for a while that as seed oils lower LDL, they also RAISE oxidized LDL and Lp(a). (PMID: 8432867, 28503188)
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Seed oils like canola are also high in linoleic acid, an Omega-6 polyunsaturated fatty acid known to increase oxidized LDL and Lp(a), clearly raising the risk of cardiovascular disease. (PMID: 8432867, 28503188)
there's a study that I've talked about in my book where they decreased the amount of saturated fat that people had in their diet and increase the PUFA they increased the polyunsaturated fat in their diet through vegetable oils like soybean oil and they saw LDL go down but LP little-a and oxidized LDL go up suggestive of worsening atherosclerosis
another Interventional study that has been done where they decrease the amount of saturated fat in people's diet any amount of linoleic acid and they see lower LDL with more oxidized LDL and more LP little a as we talked about earlier
so when you see a study that says for instance the inflammation paper saying we looked at biomarkers of linoleic acid intake linoleic acid in the blood we've got Decades of research showing that another linoleic acid biomarker oxidized LDL is Central to the process of cardiovascular disease which is an inflammatory process right
But it would be so interesting and I I don't really want to do this experiment, but I think the experiment should be done where that's happening and people are actually looking at some of these metrics like you're talking about of endothelial function, looking at LP-PLA2, looking at LP little A, which we know goes up when people eat more seed oils, looking at oxidized LDL, which we know goes up when people eat more seed oils, and looking at, you know, it is brachial artery reactivity, whatever metric we want to look at here and saying, maybe we're missing the forest for the trees here, guys.
I will show you multiple peer-reviewed randomized controlled trials that show that seed oils do some really nasty things like increasing lipid peroxidation oxidized LDL LP little a and lppla2
suggesting that oxidized LDL goes up LP little a goes up cepct gets worse which is the endothelial marker of vascular function
so saturated fat is not harmful for humans — there is a little bit of confusion there because when we do less polyunsaturated fatty acids — AKA seed oils and more saturated fat LDL will often rise slightly 20 30 % but as I've talked about many times in the past LDL by itself is a very poor predictor of cardiovascular disease and can only be interpreted in the context of insulin resistance and overall I would say — lipid Health what we know is that if you decrease saturated fat and increased seed oils or polyunsaturated fat you end up with less LDL but more oxidized LDL and more LP little a LP little a being a subfraction of LDL that is very strongly implicated in cardiovascular disease because it seems to mop up oxidized phospholipids the gist of this the high level is that even if your LDL goes down when you're eating seed oils you're getting more of those LDL particles damaged which is a problem and even if your LDL goes up when you have more animal fat less of those LDL particles are damaged which is what you want to do
ultimately what you find is that if you're eating saturated fat from steak or butter you're going to have more LDL but you're also going to have less LP little a and less oxidized LDL and if you eat seed oils you're going to have less LDL but I think that the Cardiology Community is missing the fact that you have increased LP little a and I can show you studies to corroborate any of these or all of these assertions
increased saturated fat the fat that raises LDL which the mainstream believes causes cardiovascular disease will decrease LP little a a very strong risk factor for cardiovascular disease decreased saturated fat and increase linoleic acid will increase LP little a and will increase oxidized LDL
I think that the Cardiology Community is missing the fact that you have increased LP little a
here is a study in humans decreasing saturated fat and increasing seed oils increasing linoleic acid increases oxidized LDL and LP little a
if you're eating saturated fat from steak or butter you're going to have more LDL but you're also going to have less LP little a and less oxidized LDL
decreased saturated fat and increase linoleic acid will increase LP little a and will increase oxidized LDL
these are not good things and they are clearly indications of increased inflammation with seed oils like this
we see this very clearly in the medic literature which shows that when more seed oils are introduced into the human diet inflammatory markers like oxidized LDL LP ltil a lpa2 and CRP C reactive protein go up
How seed oils can be heart healthy when they raise oxidation of your LDL and raise LP little a is beyond me
there's good evidence that seed oils increase oxidized LDL lpp2 all of these are markers for increased rates of cardiovascular disease
and there are multiple randomized controled trials in humans showing that when you feed seed oils versus olive oil or versus animal fats you certainly see an uptick in oxidized LDL and LP little a so indicators of LDL oxidation