Paul Saladino· MD
Excess linoleic acid in the diet leads to increased production of 4HNE (& OxLAMs).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Excess linoleic acid in the diet leads to increased production of 4HNE (& OxLAMs).
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Increasing dietary linoleic acid INCREASED oxylipins in humans (PMID: 35701670, 32923921)
there are some pretty good studies showing that lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans okay the results show that lowering dietary linoleic acid can reduce the synthesis and or accumulation of oxidized linoleic acid derivatives that have been implicated in a variety of pathological conditions
high linoleic acid diet and increasing oxidative stress in humans
if you lower dietary linoleic acid in your diet you are going to lower bioactive oxidized linoleic acid metabolites that's what this paper from chris ramsen's group is showing
there's mechanistic probability there with these ox lambs from omega-6 fatty acids we've seen all this other research with pregnancy and obesity linoleic acids atheromas oxidative stress markers reducing linoleic acid reduces oxalians etc in rats it relates to cardiac dysfunction
lowering dietary linoleic acid reduces bioactive oxidizing little anti-gas metabolites in humans these are the ox lambs these are the putative uh instigators of oxidative stress in humans and what we know if you eat less than oleic acid you will decrease linoleic acid metabolites in humans
we know that when you lower linoleic acid even in humans we see lower levels of oxidized linoleic acid metabolites there's a really interesting study from 2012 there's a really interesting study from 2012 by Chris ramsden that shows that when you put people on a diet of lower amounts of linoleic acid for 12 weeks this was actually done in a population that had chronic headaches uh oxlams oxidative products of linoleic acid metabolism significantly decreased
lowering dietary linoleic acid decreases oxidized linoleic acid metabolites in humans these are things like 9 and 13 hold these are not associated with good outcomes
lowering dietary linolic acid reduces bioactive oxidized lenic acid metabolites in humans again feel free to read these guys if you have any questions or rebuttal or concerns please put it in the comments but you can see here that Chris Ramen did a study where he decrease the amount of linolic acid in the diet for humans with headaches and the amount of ox Lambs including the Heats and the Hodes was decreased
but if you read this study carefully you will see that in both groups whether you have a cc or a TT for your fads one genotype at this risk Alo RS 17455 you will have increased Ox lams increased oxidative products of lenic acid metabolism with more linolic acid in your diet
but when you eat more linolic acid you have more of the Hodes and the Heats in your body