Responding to Layne Norton on SEED OILS

PS

Paul Saladino35m · 2023-12-14

Claims Made

76

Claims Supported

44

Support Rate

58%

Support rate

44 of 76 claims supported

44 supported32 partial / not

Claims from this content

55

Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.Well SupportedBreakdown products of linoleic acid, such as 4-HNE and 13-HODE, are associated with pathological fat cell phenotypes and insulin resistance.Well SupportedLowering dietary linoleic acid in humans reduces the production of oxidized linoleic acid metabolites implicated in oxidative stress.Well SupportedIncreased linoleic acid consumption leads to accumulation in adipose tissue and LDL particles, making LDL more susceptible to oxidation.Well Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Polyunsaturated fats may interfere with normal metabolism, potentially leading to pathological insulin resistance at the adipocyte level.

Well SupportedSoybean oil consumption increases LPPla2, a particle involved in cleaving oxidized phospholipids in LDL.

Not SupportedThe quality of randomized controlled trials on seed oils is often poor, leading to a flawed argument that they are benign or beneficial for cardiovascular health.

Partially SupportedSeed oils may lead to increased oxidation and potentially cancer in the long term.

Partially SupportedIncreased linoleic acid intake may lead to higher incidence of heart disease, cancer, and earlier death.

Partially SupportedIncreased consumption of seed oils led to worsening death rates, particularly in women and individuals over 65, as cholesterol decreased.

Partially SupportedCommon cooking oils like soybean oil, peanut oil, and blends emit benzene, toluene, and other aromatic compounds associated with cancer when heated.

Well SupportedOxidized LDL is significantly higher in individuals with coronary artery disease compared to those without.

Partially SupportedMore polyunsaturated fat intake was associated with more cardiac events in the Sydney Diet Heart Study.

Partially SupportedHigh-fat ground beef consumption improved flow-mediated dilation and lowered systolic and diastolic blood pressure.

Partially SupportedRodents consuming more linoleic acid exhibit increased oxidative products of linoleic acid metabolism.

Partially SupportedEven if the control group in the Minnesota Coronary Survey received margarine and shortenings as saturated fat sources and potentially more trans fats, they still performed better than the higher polyunsaturated fat group.

Not SupportedMultivitamins are not equivalent to eating whole organs because organs contain numerous beneficial compounds and potential growth factors, hormones, and peptides not found in multivitamins.

Partially SupportedIn the Ozodiet Heart study, soybean oil consumption reduced serum cholesterol and coronary heart disease relapse, but the control group had high trans fat intake.

Partially SupportedAn increase in oxidized LDL in humans is directly associated with increased rates of cardiovascular disease, heart attack, stroke, and vascular problems.

Partially SupportedObesity is positively associated with 5 and 11 HETE.

Partially SupportedFumes from cooking seed oils are consistently associated with cancers, including cervical and lung cancer.

Not SupportedClaims that seed oils are harmless are derived from poorly conducted meta-analyses that included trials where the saturated fat control group was contaminated with trans fats.

Partially SupportedThe Rose Corn Oil trial suggested that corn oil and olive oil may be harmful for cardiovascular disease.

Not SupportedThe National Diet Heart Study (1962-1964) is invalid because the control group had significantly higher trans fat than the experimental group.

Partially SupportedThere is not consistent evidence that saturated fats are negative for human endothelial function.

Partially SupportedThe Sydney Diet Heart Study is considered a 'gray study' due to potential trans fat in the experimental margarine, though LDL cholesterol decreased in that group.

Partially SupportedIn a ketogenic study, individuals became more insulin sensitive when given seed oils, indicating glucose was going to inappropriate places.

Partially SupportedCanola oil increases de novo lipogenesis, which is associated with adverse health outcomes.

Partially SupportedTrans fats are harmful for the endothelium and contribute to insulin resistance, whereas polyunsaturated fats do not have the same negative impact when replacing saturated fats containing trans fats.

Partially SupportedDiets rich in monounsaturated fats affect plasma lipoproteins.

Partially SupportedSeed oils may be harmful to humans, contrary to the position that they are neutral or beneficial.

Not SupportedThe La Veterans Administration trial (1959-1968) is flawed because the control group had a 9.4-fold lower alpha-tocopherol (vitamin E) intake and a significantly greater number of heavy smokers compared to the experimental group.

Not SupportedThe St. Thomas Atherosclerosis Regression Study (STARS) (1987-1991) is a poorly constructed trial because the control group had more trans fats, and it was a multifactorial intervention.

Partially SupportedThe FADS1 (Delta-5 desaturase) genotype influences an individual's response to linoleic acid, with the TT genotype showing worse reactions.

Not SupportedThe Oslo Diet Heart Study (1958-1963) had a flawed control group that consumed nearly all of its calories from trans fat.

Not SupportedConsuming more phthalates from sources like bottled water or seed oils is detrimental.

Not SupportedThe claim that a plant-based diet is the only diet shown to reverse heart disease is a misrepresentation.

Partially SupportedSeed oils contain phthalates at levels 45 to 396 times higher than bottled water, which are estrogen-mimicking compounds.

Not SupportedThe Oslo Diet Heart Study is flawed because the control group consumed 99.6% trans fat and the experimental group consumed soybean oil.

Partially SupportedHigher levels of linoleic acid and arachidonic acid in LDL particles are associated with atherosclerosis and coronary artery disease.

Partially SupportedReplacing dairy fat with rapeseed oil caused rapid improvement in hyperlipidemia but a significant increase in Lp(a).

Partially SupportedCooking oil fumes, including from seed oils, are associated with cancers.

Not SupportedThe 1960-1967 Medical Research Council trial is flawed due to control group diet and mixed intervention.

Partially SupportedSeed oils can contain heavy metals like cadmium and lead, as well as antimony, which leach from plastic bottles.

Partially SupportedExposure to cooking oil fumes without hoods is associated with a dose-response increase in cervical cancers.

Partially SupportedThe chance that the Oslo Diet Heart Study results occurred by anything other than a real finding suggesting polyunsaturated fats are harmful in cardiovascular disease is less than one in a thousand.

Partially SupportedDefects in macrophage efferocytosis are linked to the progression of atherosclerosis.

Partially Supported12-HETE downregulates monocyte-derived macrophage efferocytosis, which can worsen atherosclerosis progression.

Not SupportedFumes produced during cooking with seed oils are associated with cancer.

Partially SupportedMeta-analyses can be misleading if individual trials are not examined in detail, as pooled risk ratios can obscure significant flaws within studies.

Partially SupportedLp(a) acts as a scavenger for oxidized phospholipids, and correcting LDL levels for Lp(a) reduces the apparent association between LDL and cardiovascular disease.

Not SupportedMeta-analyses on saturated fat versus polyunsaturated fat effects on glucose-insulin homeostasis are flawed because most trials include trans fats in the saturated fat arms.

Partially SupportedReplacing saturated fat with polyunsaturated fats may have a slightly positive effect on cancer mortality.

Partially SupportedHigh trans fat beverages, but not saturated fat beverages, caused an acute reduction in postprandial vascular endothelial function.

Partially SupportedHuman randomized controlled data favors diets rich in saturated fat over seed oils.