Paul Saladino· MD
LA elevated apoB, ox-LDL, and Lp-PLA2.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
LA elevated apoB, ox-LDL, and Lp-PLA2.
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an increase in plasma linealic acid following an intake of soil oil was independently associated with LP-PLA2 activity LP-PLA2 activity which was also related to apob oxidized LDL and c-e-p-i-c-t which is a vascular Health indicator
there's a study in humans showing that soybean oil consumption increases lppla2 is a particle associated with LDL that is involved in cleaving oxidized phospholipids and LDL so that's probably not a good thing if you're increasing lppla2
we know that when there is a lot of lysop phospholine in LDL particles they are transformed from minimally modified LDL to oxidized LDL and that these oxidized non-esterified fatty acids freed from the phospholipid by lipoprotein Associated pla2 are inflammatory at the level of the endothelium Etc
if you populate the membranes of your cells your mitochondria and your membranes of your lowdensity Li protein cholesterol particles with more lenic acid that polyunsaturated fat is more susceptible to oxidation and potentially cleavage by lpa2 lipoprotein Associated phospholipase A2 leading to an oxidized nonesterified fatty acid and lysop phospholine in the LDL particle