Multiple controlled trials in humans, many of which are randomized, show significant negat

Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.

Well SupportedDecreasing monounsaturated and saturated fat while increasing polyunsaturated fat intake, keeping total fat stable, decreased total testosterone by 15% in one study.

Well SupportedIncreased linoleic acid consumption leads to accumulation in adipose tissue and LDL particles, making LDL more susceptible to oxidation.

Well SupportedSaturated fat can be beneficial for obese or metabolically unhealthy individuals, especially when consumed with starch and sugar.

Well Supported