Paul Saladino· MD
Increased LDL oxidation from increased dietary LA
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Increased LDL oxidation from increased dietary LA
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and I think that if we get too much six in our diet it's a problem there's evidence that LDL that's are enriched in linoleic acid which is the main omega-6 might be more highly oxidized evil
so this one is lowering dietary linolic acid reduces bioactive oxidized lenic acid metabolites in humans so people know that I've been talking about linolic acid a lot and as nadir and I are talking about here and I'll I'll show this on the next paper as well I'll show that one real quickly the when we eat more linolic acid it appears that there is a strong increase in hydroxy fatty acids derived from linolic acid in human low density lipoproteins of atherosclerotic patients
if we eat more linoleic acid is our ldl enriched in linoleic acid and it's been shown repeatedly in human studies that that happens and that when that happens the ldl becomes more oxidized
we know that polyunsaturated fatty acids accumulate in our bodies especially in the adipose tissue there are good studies showing that the higher the amount of linoleic acid in
because there's solid evidence that increased linoleic acid in the human diet will increase the propensity of LDL yeah I mean we'll get it we can get into seed oils yeah we'll get into the linoleic acid on Steve oils that's not a problem but inside the arterial wall is a different story
that LDL that's enriched in linoleic acid because people are eating seed oils is like more like a bomb that LDL is much more likely to become oxidized by the macrophage environment more likely to become oxidized LDL
when we eat more linoleic acid as more seed oils we're going to accumulate that linoleic acid in our adipose tissue that's the only real indicator of how much linoleic acid we consumed we're also going to accumulate that linoleic acid in our LDL particles that LDL enriched in linoleic acid is more likely to be oxidized into the sub-endothelial space
there are multiple trials showing that more linolic acid this 18 carbon Omega 6 polyunsaturated fatty acid is consumed there is an increased amount of oxidized LDL in humans
high levels of arachidonic acid and linolic acids could increase LDL oxidation and atherosclerotic plaqu formation