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Linoleic acid is harmful for humans — Whalespan

Content›Video›Linoleic acid is harmful for…

Linoleic acid is harmful for humans

Paul Saladino9m · 2022-05-13

Claims Made

16

Claims Supported

16

Support Rate

100%

Support rate

16 of 16 claims supported

16 supported0 partial / not

Claims from this content

14

✓Well SupportedLowering dietary linoleic acid in humans reduces the production of oxidized linoleic acid metabolites implicated in oxidative stress.✓Well SupportedThe breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.✓Well SupportedAdipose tissue levels are a more accurate indicator of linoleic acid consumption than blood levels.✓Well SupportedSubcutaneous adipose tissue linoleic acid levels correlate with cardiovascular disease incidence.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Maternal linoleic acid intake is strongly correlated with childhood obesity.

✓Well SupportedMaternal plasma levels of omega-6 polyunsaturated fatty acids during late pregnancy positively predicted offspring fat mass at 4 and 6 years of age.

◐Partially SupportedHigher percentages of omega-6 highly unsaturated fatty acids in adipose tissue correlate strongly with higher coronary heart disease mortality.

◐Partially SupportedA high linoleic acid diet increased urinary excretion of an oxidative product and decreased nitric oxide metabolites compared to a diet rich in saturated fatty acids.

◐Partially SupportedThe enzyme 15-lipoxygenase is involved in forming oxylams from linoleic acid, which may play a problematic role in atherogenesis.

◐Partially SupportedHistorical overestimation of linoleic acid requirements may have contributed to underestimating the role of omega-6 PUFAs in adipose tissue development.

◐Partially SupportedChronic consumption of a diet rich in omega-6 polyunsaturated fatty acids for four weeks can cause mitochondrial damage and cardiac dysfunction in male rats.

◐Partially SupportedExcess consumption of linoleic acid in seed oils, grains, seeds, and nuts is a major evolutionary inconsistency driving metabolic dysfunction.

◐Partially SupportedOmega-6 polyunsaturated fatty acids, including linoleic acid, appear to be problematic for cardiovascular health.

◐Partially SupportedDisequilibrium in polyunsaturated fatty acid metabolism may contribute to excess adipose tissue development.