The breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.

“the other problem with linoleic acid is ox lambs oxidative products of linoleic metabolism the fact that linoleic acid is known to break down into four hydroxy known and all nine and 13 hold and these create major problems for us as well”

“lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites if you lower the amount of linoleic acid in your diet by predominantly avoiding nuts and seeds corn and soy vegetable oils and maybe avoiding pork that's fed a bunch of corn and soy if it's super fatty you can lower the levels of 9 and 13 hydroxy octadecanoa dienoic acid 9 and 13 hot or 4 hne 4 hydroxynol”

“lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans it's just a paper connecting the fact that if you decrease you know linoleic acid you will have less 4-h and e less 9 and 13 hold”

“how do you get high levels of 4-h and e hat tip to tucker goodrich who i'm going to have on the podcast you eat lots of linoleic acid”

“linoleic acid can break down via either an enzymatic breakdown with 12 15 lipoxygenase or free radical radical oxygenation into 9 and 13 hpode or 9 and 13 hode which we'll talk about”

“these molecules specifically 13 hoed and 4h and e have been implicated in so many problematic things in the human body increased rates of cancer basically breaking mitochondria breaking fat cells”

“there's good evidence that the breakdown products of linolenic acid are associated with that phenotype and fat cells these are things like 4h and e 13 d e there's a code and so linoleic acid is poly antibody fat so we see okay the breakdown parts of linoleic acid are associated with that pathological king type”

“the breakdown products linoleic acid 4-hme 13-hoe are associated with all these problems so it looks to be problematic it looks to be guilty but it could just be inflammatory phenotype or some sort of oxidative stress it's oxidizing linoleic acid that's already in the membrane but you can pretty much find evidence for every step of the way along the path”

“is it possible that linoleic acid is getting incorporated into cell membranes but somebody's hitting that that that is very fragile or that ox lambs these bioactive oxidized linoleic acid metabolites they have long names just call them 9 and 13 hoed for short or 9 and 13 oxo ode oxo ode are causing issues in humans that have high linoleic acid diets i would say very likely”

“the way you develop disease is you get evolutionarily inappropriate levels of vitality acid potentially to break down products linoleic acid 4-h and e 13-hole are associated with all these problems so it looks to be problematic it looks to be guilty but it could just be an inflammatory phenotype or some sort of oxidative stress it's oxidizing linoleic acid it's already in the membrane”

“if you look at the literature there's evidence that in there's increased LDL oxidation when there's increased seed oils increased linoleic acids oxidation of LDL in the sub-endothelial space is probably a very bad thing so in the Jerusalem nutrition study people are not reading more seed oils had more LD oxidation”