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Controversial Thoughts is BACK!

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Paul Saladino26m · 2020-08-13

Support Rate

78%

52 of 67 claims supported

Support rate

52 of 67 claims supported

52 supported15 partial / not

Claims from this content

61

Well SupportedStearic acid ingestion increases circulating C18 triglycerides and activates mitochondrial beta-oxidation.Well SupportedOxidized LDL, where omega-6 fatty acids have oxidized into MDA and HNE, is essential for the initiation of atherosclerosis in humans.Not SupportedPaul Saladino avoids pork fed corn, soy, and seed oils due to high linoleic acid accumulation.Well SupportedThe breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.Well SupportedPaul Saladino has a fasting blood sugar of 74mg/dl, low glycemic variability, and clear insulin sensitivity while consuming a few tablespoons of honey daily.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well SupportedGrass-fed, grass-finished ruminant meat contains less than 2% linoleic acid.

Well SupportedMetabolic dysfunction can be identified by elevated fasting insulin and postprandial insulin resistance observed on a CGM.

Well SupportedIn metabolically unhealthy individuals, carbohydrates can be problematic and should be eliminated, but they do not cause weight gain in metabolically healthy individuals.

Well SupportedRaw organic honey, when consumed in moderate to large amounts, does not negatively impact blood sugar levels for the speaker.

Well SupportedDietary stearic acid reduced visceral adipose tissue by 70% and increased lean body mass in rats compared to oleic and linoleic acid diets.

Well SupportedIn metabolically healthy individuals, including local, organic, raw honey in the diet is acceptable and not equivalent to fear-mongering about sugar.

Well SupportedSeverely limiting carbohydrates can cause physiological insulin resistance.

Well SupportedFasting insulin is the easiest lab metric to monitor for potential negative effects of consuming fruit and honey, especially if linoleic acid intake is low.

Well SupportedLowering dietary linoleic acid decreases oxidized linoleic acid metabolites in humans, which are associated with poor outcomes.

Well SupportedBeef organ capsules from Heart & Soil contain bioavailable copper, kidney, spleen, pancreas, and heart.

Well SupportedExcessive dietary linoleic acid is a primary cause of insulin resistance and metabolic dysfunction.

Partially SupportedMaintaining a low-carb diet involves consuming approximately 15% of calories from carbohydrates, even with honey consumption.

Partially SupportedReducing linoleic acid intake is a key strategy for resolving underlying metabolic dysfunction and enabling carbohydrate tolerance.

Not SupportedExcess linoleic acid is associated with massive harm in humans and animal models.

Partially SupportedExcess linoleic acid contributes to metabolic dysfunction and carbohydrate intolerance.

Partially SupportedSumo wrestlers consuming a high-caloric, low-fat, unprocessed diet maintain insulin sensitivity while actively training, but may develop insulin resistance after ceasing intense physical activity.

Partially SupportedFasting insulin, C-peptide, and hs-CRP are better indicators of metabolic health than absolute glucose levels.

Partially SupportedLinoleic acid levels in adipose tissue of US adults have increased by 136% over the last half-century, correlating with increased dietary intake from vegetable oils, nuts, seeds, and corn/soy-fed pork.

Partially SupportedDecreasing carbohydrates can be helpful for individuals with metabolic illness, but understanding the origin of the metabolic state is also critical.

Partially SupportedThe Tukisenta population consumes a high carbohydrate diet and shows very low incidence of cardiomyopathy, hypertension, and coronary heart disease.

Partially SupportedMetabolically healthy individuals can consume carbohydrates without developing diabetes if they avoid polyunsaturated fats at evolutionarily inconsistent levels.

Partially SupportedLinoleic acid and stearic acid levels can be assessed via omega-3/omega-6 ratios or blood/RBC levels.

Partially SupportedLow-carb diets can be effective for weight loss and provide relief for many individuals.

Not SupportedPork fed grains may be problematic due to glyphosate in grains increasing linoleic acid content in pork fat.

Partially SupportedIt is important to calculate the amount of linoleic acid consumed from various food sources.

Partially SupportedElectrolyte imbalance indicated by cramps or palpitations on a ketogenic diet may require reintroducing carbohydrates.

Partially SupportedFor some animals, including potentially humans, linoleic acid in the diet signals hibernation, winter, fattening, and scarcity.

Partially SupportedA CGM can reveal metabolic dysfunction, as shown by a large blood sugar spike after eating beer-battered fish and coleslaw.

Partially SupportedLow-carb diets can be valuable for humans but did not cause the metabolic dysfunction they aim to address.

Partially SupportedA rat study showed that feeding rats starch and stearic acid led to the loss of all abdominal fat.

Partially SupportedPlasma oxylans are elevated in Alzheimer's dementia and NASH and can serve as biomarkers.

Partially SupportedA client consuming a diet rich in pork had a linoleic acid percentage of 30% in their blood.

Partially SupportedReducing dietary linoleic acid can decrease the synthesis and accumulation of oxidized linoleic acid derivatives implicated in pathological conditions.

Partially SupportedA hemoglobin A1c of 4.8 indicates an average blood sugar of approximately 90 mg/dL.

Partially SupportedKetogenic and low-carb diets are not necessary forever for metabolically healthy individuals who can include carbohydrates.

Not SupportedEvolutionarily inconsistent levels of linoleic acid in the diet can lead to visceral adipose tissue gain, reduced insulin sensitivity, and metabolic dysfunction.

Partially SupportedA diet low in linoleic acid can treat fatty liver disease in youth with metabolic dysfunction within 12 weeks.

Partially SupportedA blood sugar response to 25 grams of honey, reaching 174 mg/dL, suggests physiological insulin resistance from prior low-carb intake or a compromised metabolism.

Partially SupportedLinoleic acid has been associated with increased carboxymethyllysine, an endogenous product of advanced glycation.

Partially SupportedLevels of 9 and 13 HOE are significantly higher in Alzheimer's patients compared to healthy controls, and total HOE levels correlate with dementia severity.

Not SupportedConcerns exist about the long-term effects of ketosis, as evidenced by a continuous glucose monitor from someone on a zero-carb diet for five years showing high blood sugar levels.

Partially SupportedMeat not fed corn and soy is affordable and obtainable by most people.

Partially SupportedReintroducing carbohydrates into the diet is problematic if linoleic acid is not significantly reduced, as it can lead to intolerance and other issues.

Partially SupportedExcessive linoleic acid intake from sources like nut butters and nuts can hinder weight loss on ketogenic diets.

Partially SupportedThe speaker's continuous glucose monitor analytics show a very low standard deviation, a low maximum value, and an average blood sugar of 73 mg/dL, with zero spikes above the reference range.

Partially SupportedIndividuals with a hemoglobin A1c of 6.3 or higher are more likely to be concerned about advanced glycation end products than those with lower levels.

Partially SupportedThe speaker's hemoglobin A1c levels indicate that fructose is not causing them glycation issues.

Partially SupportedExcess linoleic acid is believed to cause underlying insulin resistance and disrupt metabolism.

Partially SupportedLinoleic acid percentage can be measured in blood.

Partially SupportedThe speaker's red blood cell linoleic acid percentage was 5.4%, indicating a reduced intake or improved metabolism of linoleic acid.

Partially SupportedFat from animals fed corn and soy can contribute to excess linoleic acid intake.

Partially SupportedChoosing pork from pigs not fed high amounts of corn and soy, or opting for red meat (especially grass-fed) or organ meats like liver, can reduce dietary linoleic acid intake.

Partially SupportedThe Catawba population in Melanesia, consuming a high carbohydrate and low fat diet, are apparently free from stroke and ischemic heart disease.

Partially SupportedIndividuals on a five-year zero-carb diet can exhibit elevated fasting blood sugar levels (120-124 mg/dL) and a higher area under the curve for glucose.

Partially SupportedDietary changes like eliminating carbohydrates are not a lasting solution if the underlying cause of metabolic problems is not addressed.

Partially SupportedAn average blood sugar of 134 mg/dL corresponds to a hemoglobin A1c of 6.3.