Oxidized LDL, where omega-6 fatty acids have oxidized into MDA and HNE, is essential for the initiation of atherosclerosis in humans.

“Oxidized derivatives of linoleic acid, 9- and 13-hydroxyoctadecadienoic acid (9-HODE and 13-HODE), are abundant in atherosclerotic lesions.”

“Oxidized derivatives of linoleic acid, 9- and 13-hydroxyoctadecadienoic acid (9-HODE and 13-HODE), are abundant in atherosclerotic lesions.”

“Consuming higher amounts of linoleic acid has been shown to increase oxidation of LDL particles in multiple experiments, so it’s not terribly surprising that eating conventionally raised eggs would do the same thing”

“this study shows that in people with atherosclerosis there is between a 30 and 100 fold increase in oxidative linoleic acid metabolites in those with atherosclerosis relative to healthy controls meaning that ldl is enriched in oxidative products of linoleic acid in those with atherosclerosis”

“the content of nine hoed which is one of these oxidative products of linoleic acid metabolism in the ldl of atherosclerotic patients age 69 to 94 increased 30 to 100 fold when compared with young healthy individuals”

“A strong increase in hydroxy fatty acids derived from linoleic acid in humans low density of proteins of atherosclerotic patients this has to do with the ox ldl that dave and i were talking about”

“and in both age groups there was a 20 to 30 and 100f fold increase in the products of oxidative oxidation of linolic acid in those with atherosclerosis”

“the more more our LDL gets enriched with linolic acid the more oxidized it becomes the more susceptible to oxidation it becomes so we don't need to worry about LDL we should probably be thinking about oxidized LDL and both of these papers are showing us that the more linolic acid we eat the more of these Ox lams the nine and 13 H the four h& molecules accumulate in our LDL molecules and that is much more increased in patients with atherosclerosis”

“it's the major toxic component of ox ldl it's derived exclusively from omega-6 fats linoleic acid and arachidonic acid”

“an oxidized ldl is an ldl in which the omega-6 fatty acids have oxidized that means the linoleic acid and the arachidonic acid has been converted into two linoleic acid and arachidonic acid metabolites mda and hne when that happens macrophages will hoover up oxidized ldl until they become foam cells back to that lovely term essential it turns out that oxidized ldl and therefore the oxidation of n6 fats is essential to the initiation of atherosclerosis in humans”

“this is a paper showing a strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients ... the amount of nine hoed in the ldl of those with atherosclerosis was increased by huge factors a factor of 20 in the younger age group and a factor of 30 to 100 in the older age group”

“the connecting piece of the hypothesis would then be if we eat more linoleic acid is our ldl enriched in linoleic acid and it's been shown repeatedly in human studies that that happens and that when that happens the ldl becomes more oxidized right”

“more linoleic acid in the human diet increases the amount of linoleic acid in the LDL particle and if there's more linoleic acid in the LDL particle that LDL is more susceptible to oxidation and we know that oxidation is a prerequisite for the formation of foam cells which are the beginning of atherosclerosis”

“you eat more linoleic acid more linoleic acid in your LDL and more linoleic acid in your LDL more oxidized LDL that each each step a goes to B goes to C that's all clearly shown in the medical literature”

“the more linoleic acid you need the more susceptible to oxidation your LDL is that's a very very bad thing”

“and there's a great article it's called omega-6 veg boils is a driver of coronary heart disease it's by James D Nic d d Nicol Antonio and James uh o'keef and basically they have a rundown in this article talking about how lolic acid is directly implicated in cardiovascular disease and they have basically 21 points that obliterate a linolic acid as as like one of the a primary promoters and what they say here I'm going to read a couple of them they say greater amounts of linolic acid oxidation products are found in LDL and plasma of patients with Asos sclerosis”