There are multiple controlled trials in humans, many of which are randomized, showing sign

Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.

Well SupportedOxidized LDL, where omega-6 fatty acids have oxidized into MDA and HNE, is essential for the initiation of atherosclerosis in humans.

Well SupportedDecreasing monounsaturated and saturated fat while increasing polyunsaturated fat intake, keeping total fat stable, decreased total testosterone by 15% in one study.

Well SupportedSaturated fat can be beneficial for obese or metabolically unhealthy individuals, especially when consumed with starch and sugar.

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