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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How do we keep our fat cells healthy? — Whalespan

Content›Video›How do we keep our fat cells…

How do we keep our fat cells healthy?

Paul Saladino6m · 2022-05-19

Claims Made

11

Claims Supported

9

Support Rate

82%

Support rate

9 of 11 claims supported

9 supported2 partial / not

Claims from this content

11

✓Well SupportedBreakdown products of linoleic acid, such as 4-HNE and 13-HODE, are associated with pathological fat cell phenotypes and insulin resistance.✓Well SupportedBroken fat cells cause insulin resistance, and fixing them may lead to weight gain if dietary habits remain unchanged.✓Well SupportedThe breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.✕Not SupportedThe notion that LDL cholesterol alone is sufficient to initiate atherosclerotic plaque and is the main driver of atherosclerosis is likely to be disproven.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Cell membranes enriched in linoleic acid are more susceptible to oxidation compared to saturated fats like palmitic or stearic acid.

◐Partially SupportedEvolutionarily consistent dietary patterns, such as those found in animal foods sought by ancestors, are unlikely to be inherently bad for humans.

◐Partially SupportedMaintaining healthy fat cells is best achieved with animal fats and minimal amounts of polyunsaturated and monounsaturated fats.

◐Partially SupportedSaturated fat may promote insulin resistance, which is beneficial for hyperplasia over hypertrophy.

◐Partially SupportedIncreased oxidized LDL is linked to increased disease-related fat cells.

◐Partially SupportedExcessive insulin sensitivity in fat cells can lead to uncontrolled growth because insulin is anti-catabolic.

✕Not SupportedLinoleic acid is associated with inflammatory phenotype and oxidative stress.