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Nick Bare interviews Paul on The Dangers of Seed oils

PS

Paul Saladino1h 51m · 2022-02-15

Support Rate

72%

172 of 238 claims supported

Support rate

172 of 238 claims supported

172 supported66 partial / not

Claims from this content

183

Well SupportedAn animal-based diet prioritizing meat, organs, ripe fruit, and honey is evolutionarily consistent for humans.Well SupportedStearic acid ingestion increases circulating C18 triglycerides and activates mitochondrial beta-oxidation.Well SupportedExcessive intake of linoleic acid arises from its concentration and abundance in processed seed oils.Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Well SupportedThe Rotterdam Study indicated a correlation between higher intake of Vitamin K2 and improved health outcomes.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well Supported

Hunter-gatherer societies offer comparable life expectancy to modern populations if individuals survive to adolescence, with a better healthspan.

Well SupportedContinuous Glucose Monitors (CGMs) provide valuable insights into how various foods and lifestyle factors affect glucose levels, and can lead to behavioral modification.

Well SupportedAdding fruit and honey back into the diet improved muscle fullness, resolved cramps and heart palpitations, improved sleep, and restored testosterone levels above 700.

Well SupportedOdd-chain fatty acids found in dairy fats are consistently and strongly associated with improved health outcomes in humans.

Well SupportedLinoleic acid content varies significantly across foods, with seed oils containing 20-55% and tallow/butter containing 1-2%.

Well SupportedThe breakdown products of linoleic acid, specifically 4-HNE and 13-HODE, are implicated in increasing cancer rates, breaking down mitochondria, and damaging fat cells.

Well SupportedThousands of people are following a carnivore diet and experiencing changes in various diseases, including autoimmune disease.

Well SupportedExcess linoleic acid and 4-HNE in fat cells prevent them from dividing, causing hypertrophy instead of hyperplasia.

Well SupportedStearic acid, enriched in animal foods and absent in plant foods, signals the body to burn fat, and its deprivation leads to fragmented mitochondria.

Well SupportedImpaired wound healing at the endothelial level in individuals with insulin resistance prevents proper repair, leading to the initiation of atherosclerosis.

Well SupportedA fasting insulin level below 3 micro IU/mL is ideal, below 5 micro IU/mL is acceptable, and above 5 is unacceptable.

Not SupportedThe reference range for fasting insulin, which extends up to 22-26 micro IU/mL, is too high and doctors do not flag levels within this range as problematic.

Not SupportedIt is recommended to remove seed oils such as canola, sunflower, safflower, soybean, grape seed, and rice bran oils from the diet completely.

Well SupportedVitamin K2 is found in animal foods and is essential for calcium movement, potentially reducing heart disease and aortic valve calcification.

Well SupportedTallow and butter are better cooking fats than olive oil due to lower monounsaturated fat, higher saturated fat, and very little linoleic acid.

Well SupportedRoux-en-Y gastric bypass surgery is an effective treatment for obesity by disrupting the endocannabinoid pathway signaling between the brain and gut.

Well SupportedHigher intake of linoleic acid is likely worse for humans from an evolutionary perspective.

Well SupportedAdopting a carnivore diet followed by an animal-based diet for four years resolved the speaker's eczema and asthma.

Well SupportedPaul Saladino's eczema and asthma improved significantly after adopting a carnivore diet, eliminating plant and fungal foods.

Not SupportedThe evidence directly implicating LDL cholesterol in the formation of atherosclerotic plaque or heart disease progression is weak.

Well SupportedReducing linoleic acid intake is predicted to be the most significant health improvement.

Well SupportedMinimizing or eliminating seed oils from the diet improves overall health and can positively impact various bodily functions.

Well SupportedThere is a temporal association between increased seed oil consumption and rises in obesity, asthma, diabetes, and chronic illness.

Well SupportedBlocking CB1 cannabinoid receptors can reduce hunger and aid weight loss, but may have mood-related side effects.

Well SupportedGrass-fed red meat is the best animal protein source because ruminants convert PUFAs to saturated fats.

Well SupportedIndividuals on ketogenic diets may need to increase salt intake due to insufficient insulin signaling at the kidney for electrolyte retention.

Well SupportedHumans are programmed to eat meat, as evidenced by its central role in the human diet for hundreds of thousands of years and its presence deep in human DNA.

Well SupportedDynamic glucose responses to simple carbohydrate intake observed with CGMs are more informative than fasting glucose levels for identifying metabolic issues.

Well SupportedIndividuals with significant autoimmune disorders or digestion problems may benefit from an elimination diet like a carnivore diet.

Well SupportedFasting insulin levels should be used to diagnose diabetes, as current reference ranges are too high.

Well SupportedIncreased and evolutionarily inconsistent consumption of linoleic acid causes metabolic dysfunction, insulin resistance, and related chronic diseases.

Well SupportedHoney contains nitric oxide metabolites and increases nitric oxide production, differentiating it from sucrose and Coca-Cola.

Well SupportedIn 1900, 100% of dietary oil intake was from animal fat, and in the absence of processed carbohydrates, this was not associated with chronic disease.

Well SupportedMinimizing linoleic acid intake and maximizing stearic acid intake activates mitochondrial fat burning for weight loss.

Well SupportedIncreased consumption of vegetable oils like soybean and canola is associated with the rise in chronic disease.

Well SupportedConsuming more than 4% of daily calories from linoleic acid is associated with chronic disease.

Partially SupportedSaturated fats have no double bonds, monounsaturated fats have one, and polyunsaturated fats have two or more.

Well SupportedLDL cholesterol may be less significant for atherosclerosis in metabolically healthy individuals compared to those with diabetes or metabolic dyslipidemia.

Well SupportedLinoleic acid consumption increases fat accumulation likely due to CB1 receptor activation.

Well SupportedPhysiological insulin resistance is a normal and protective state in a ketogenic state.

Well SupportedConsuming carbohydrates, such as fruit and honey, can help reintroduce phasic insulin signaling and prevent physiological consequences of prolonged ketosis.

Well SupportedSeed oils were historically used as machine lubricants and are now a major part of the human food supply, unlike animal fats.

Well SupportedHumans should optimize stearic acid and minimize linoleic acid in their diet, potentially by avoiding seed oils.

Well SupportedMaintaining insulin sensitivity is critical for individuals, and checking fasting insulin levels is important for assessing metabolic health.

Well SupportedAnimal foods are more bioavailable in terms of nutrients because they share the same operating system as humans.

Partially SupportedSHBG was in the 120s when following a ketogenic diet and in the 70s when measured non-fasting between July and August.

Well SupportedInterpreting blood work should involve triangulating fasting insulin, fasting glucose, and hemoglobin A1c, or using a CGM.

Well SupportedImproving metabolic health long-term involves reducing seed oils and processed sugars.

Well SupportedBioavailable zinc is primarily obtained from animal foods, with minimal to no bioavailability from plant sources.

Well SupportedHunter-gatherer tribes have high rates of maternal and infant mortality.

Well SupportedFresh squeezed orange juice results in a different physiological response in the human body compared to an equivalent amount of isolated fructose or sucrose.

Well SupportedThe speaker takes the 'Whole Package' supplement from Hardened Soil daily.

Well SupportedIntroducing seed oils, corn flour, and wheat flour into the Hadza diet led to obesity.

Partially SupportedFats higher in monounsaturated and polyunsaturated fatty acids tend to be more liquid due to kinks created by double bonds.

Partially SupportedThe carbon between two double bonds in polyunsaturated fatty acids is unstable and vulnerable to lipid peroxidation.

Partially SupportedPathological insulin resistance is characterized by an overwhelming systemic refusal of cells to respond to insulin signals.

Well SupportedPaul Saladino's plan includes sun exposure, ocean swimming, consuming liver, heart, and raw testicle.

Well SupportedSeed oils, processed sugar, and gluten are the top three most problematic dietary components for humans.

Well SupportedSaturated fat is essential for the human body and is associated with increases in HDL cholesterol and testosterone, and is a backbone for cholesterol molecule formation.

Well SupportedMajor dietary sources of linoleic acid include vegetable oils and sometimes adulterated avocado and olive oils.

Well SupportedA tablespoon of soybean oil requires eating an "insane amount" of soybeans, and a tablespoon of corn oil requires consuming approximately 25 ears of corn.

Well SupportedLinoleic acid is susceptible to oxidative damage, leading to the formation of toxic breakdown products.

Well SupportedDesiccated organ capsules can be an option for vegans who have a psychological barrier to consuming fresh organs.

Well SupportedPathologic insulin resistance originates in broken fat cells that signal tissues to resist insulin, leading to rising glucose levels.

Well SupportedHunter-gatherer tribes do not suffer from chronic diseases like diabetes, heart attacks, or autoimmune conditions, unlike Westernized populations.

Partially SupportedOlive oil has a linoleic acid content of 9.8%, which is higher than that found in most ruminant and species-appropriate fed monogastric animal fats.

Partially SupportedPrior to 1911, all dietary fat consumed in the US was animal-derived, with seed oils introduced around that time.

Well SupportedLinoleic acid is present in varying amounts in all animal fats, including meat.

Partially SupportedStearic acid is best obtained from animal fat sources like tallow rather than cocoa butter.

Well SupportedUnsaturated fats are more volatile and susceptible to oxidation compared to saturated fats due to the presence of double bonds.

Partially SupportedIndividuals with full-blown diabetes may need to limit fruit intake if they experience significant blood sugar reactions.

Partially SupportedIncreased consumption of vegetable oils since 1960 correlates with higher rates of diabetes, obesity, and chronic disease.

Partially SupportedMetabolic dysfunction, where tissues refuse insulin despite carbohydrate intake, is a progression towards type 2 diabetes.

Partially SupportedMetabolic dysfunction involves hypertrophied fat cells that are unable to divide.

Partially SupportedIncreasing amounts of red meat in the diet may lead to improved outcomes in inflammatory markers and other health markers, including diabetes.

Partially SupportedCurrent hunter-gatherer tribes live as long as modern humans but with significantly better vitality and a squared morbidity curve.

Not SupportedThe speaker experienced electrolyte issues, cramping, and poor recovery during a ketogenic diet in college.

Not SupportedFasting insulin reference ranges in Western medicine are too high and do not accurately reflect insulin resistance.

Partially SupportedMetabolic health can be assessed using a continuous glucose monitor, fasting insulin levels, or visceral adipose tissue measurement.

Well SupportedMany individuals in hunter-gatherer societies lived into their 70s and 80s, which is considered a long lifespan even by today's standards.

Partially SupportedBreast milk from mothers consuming a standard American diet has higher levels of linoleic acid compared to breast milk from hunter-gatherer populations.

Partially SupportedFruit is generally the least defended part of a plant, with lower levels of defense chemicals compared to stems and leaves, especially when ripe.

Partially SupportedFasting insulin levels remained stable around 3 micro iu/mL when consuming 100-200 grams of carbohydrates daily, suggesting no change in insulin sensitivity.

Partially SupportedThe position of the first double bond from the end of a fatty acid molecule determines its classification as omega-3 or omega-6.

Partially SupportedHoney is a suitable carbohydrate source because it is made by bees and contains minimal defense chemicals.

Partially SupportedIn mice, fructose consumption leads to problems like oxidative stress and fatty liver, whereas honey consumption does not cause these issues.

Partially SupportedOrgan meats ranked by perceived value include liver (highest), heart (second), and testicle (for libido).

Partially SupportedUnripe fruit may contain plant defense chemicals that decrease as the fruit ripens.

Partially SupportedStudies on linoleic acid should include a saturated fat washout period before intervention and a linoleic acid washout period after.

Partially SupportedA saturated fatty acid molecule is a straight chain of carbons and hydrogens with no double bonds, ending in a carboxylic acid group.

Partially SupportedMinimizing overall consumption is the best strategy to avoid linoleic acid as triglycerides.

Not SupportedComparing the postprandial blood glucose response from honey and Coca-Cola is a myopic view that does not reflect the full metabolic picture.

Partially SupportedConsuming organs like intestine, spleen, heart, liver, and testicle is a significant dietary hack.

Partially SupportedConsuming seed oils high in polyunsaturated fatty acids generally lowers LDL cholesterol.

Not SupportedMany olive oils contain a high amount of linoleic acid (7-21%).

Not SupportedAPOB-containing lipoproteins are not causative of atherosclerosis, although they may be involved.

Partially SupportedKetosis can be overused and is powerful medicine similar to fasting, activating genes for autophagy.

Partially SupportedPaul Saladino avoids extra cooking oils, preferring to cook meat on a grill or in pans with minimal added animal fats.

Partially SupportedTallow is high in stearic acid, an 18-carbon saturated fatty acid with positive effects in the human body.

Partially SupportedDrinking blood provides immune cells, co-factors, hormones, vitamin D, iron, and other vitamins.

Partially SupportedSome olive oil and avocado oil products are adulterated with cheaper seed oils, with up to 50% canola oil in products labeled as olive oil.

Partially SupportedFruit, as a non-processed carbohydrate source, is not a cause of weight gain for many individuals.

Partially SupportedCooking steak on a dry grill with only salt is a relatively safe restaurant preparation method.

Partially SupportedSeed oils are a significant factor contributing to obesity and appetite regulation issues.

Partially SupportedA low linoleic acid diet, rich in red meat fat and low in linoleic acid, is recommended.

Partially SupportedStearic acid, predominantly found in animal foods, is essential for human physiology and optimal health.

Not SupportedThe nutritional paradigm that vegetable oils are beneficial because they lower LDL is flawed.

Partially SupportedHigh linoleic acid seed oils that are industrially refined, bleached, and deodorized become damaged when heated, which is harmful to humans.

Partially SupportedAdipose tissue functions as an endocrine organ, releasing hormones called adipokines and cytokines.

Partially SupportedThe USDA database does not include vitamin K2, and individuals may be unaware of its importance if relying solely on apps that use this database.

Partially SupportedFruit and honey affect human physiology differently than processed sugar.

Partially SupportedAnimal fats like tallow and lard, which are higher in saturated fat, will raise LDL in many individuals.

Partially SupportedAn animal-based diet, combined with desiccated organ supplements, improved energy, mood, resilience, and resolved chronic severe cholinergic urticaria, dryness, redness, and inflammation.

Partially SupportedGastric bypass surgery may improve satiety and reduce appetite by cutting branches of the vagus nerve, disrupting the signaling of dietary cannabinoids that trigger appetite and loss of satiety.

Partially SupportedMetabolic dysfunction, characterized by insulin resistance, is the root cause of LDL-related problems, and fixing it involves improving fat cell function.

Partially SupportedIt may take six months to a year of adhering to a low linoleic acid and high stearic acid diet for insulin sensitivity to improve.

Partially SupportedExcessive oxidation can damage proteins, altering their shape and potentially causing the body to perceive them as foreign.

Partially SupportedNick Bare requests steaks be cooked on a dry grill with only salt, avoiding any added oil.

Partially SupportedAn animal-based diet can help many people by simplifying food choices and reducing problematic ingredients.

Partially SupportedFor a physiologically insulin-resistant individual, introducing carbohydrates can lower fasting blood sugar and reduce post-meal glucose spikes, resulting in a lower glucose area under the curve.

Partially SupportedBlocking the CB1 receptor with rimonabant could counteract linoleic acid effects on satiety but carries risks of depression and suicidality.

Partially SupportedCoconut oil contains primarily myristic and lauric acid and very little stearic acid.

Partially SupportedConsuming beef fat is healthy, evolutionarily consistent for humans, and associated with vanishingly low rates of chronic disease around 1900.

Partially SupportedOxidation is essential for human life.

Partially SupportedThe type of fat molecule consumed is critically important for health outcomes, not just the total caloric intake from fat.

Partially SupportedRestaurants often use seed oils like canola or soybean oil because they are cheaper and have a milder flavor than olive oil.

Partially SupportedGrass-fed meat is sourced from farms like Grass Fed Costa Rica on the Guanacaste peninsula.

Not SupportedMargarine is potentially the single greatest cause of atherosclerosis in the human diet.

Partially SupportedFoods that are evolutionarily inconsistent with the human diet should be viewed with suspicion.

Partially SupportedPepper can negatively affect gut health for some individuals.

Partially SupportedAvoiding mayonnaise is necessary to prevent seed oil consumption.

Partially SupportedGrass-fed, grass-finished beef is a good source of stearic acid.

Partially SupportedNick Bare checks ingredient labels and prefers higher quality restaurants for better food sources.

Partially SupportedNick Bare has increased his consumption of fatty red meat and adds tallow to ground beef because he feels better with a higher fat diet.

Partially SupportedThe informational content for the body from a banana is completely different than from an equivalent amount of table sugar or orange juice.

Not SupportedLinoleic acid can be detrimental.

Partially SupportedAn animal-based diet requires avoiding mayonnaise, sauces, and spreads due to their seed oil content.

Partially SupportedSeed oils are produced by concentrating linoleic acid from plant seeds and contain defense chemicals like phytic acid and phytoestrogens.

Partially SupportedHuman nutrition understanding progresses through levels from macronutrients to peptides and unknown compounds in organ meats.

Partially SupportedGenetic mutations like hyperphagia mutations and Prader-Willi syndrome can cause massive adiposity.

Partially SupportedThe vilification of cholesterol and animal fats by the medical system and the American Heart Association began around the mid-1950s.

Partially SupportedRancid or oxidized olive oil in processed foods or restaurant dishes can be detrimental to health.

Partially SupportedCertain foods, particularly those with seed oils, can trigger compulsive eating behavior.

Partially SupportedIn states of semi-starvation or ketosis, the body prioritizes glucose for essential functions and uses ketones for muscles.

Not SupportedDark chocolate is a possible source of stearic acid but is not preferred due to added sugar and other undesirable components.

Not SupportedVegetable oils were marketed as 'heart healthy' despite being problematic.

Not SupportedSeed oils are often used in barbecues, which the speaker advises against.

Partially SupportedOxidation is essential for life but excess oxidation can be problematic.

Not SupportedChickpeas in hummus can be problematic for many people due to digestive enzyme inhibitors and lectins.

Not SupportedPepper is avoided by the speaker due to being a seed spice that negatively affects their gut.

Partially SupportedSeed oils such as canola, vegetable, soybean, and sunflower seed oil are prevalent in many processed and even organic foods.

Partially SupportedIntroducing a double bond between carbons in a fatty acid molecule reduces the number of hydrogens it can bind to, leading to unsaturated fats.

Partially SupportedLinoleic acid in foods may disrupt satiety and lead to overeating, particularly with processed foods containing seed oils.

Partially SupportedPaul Saladino uses tallow only when cooking very lean meats, otherwise relying on the fat content of his meat.

Partially SupportedVitamin K2 (menaquinones, especially MK-4) is a critical form of vitamin K not included in the USDA database.

Not SupportedExcess carbohydrates are not the primary driver of long-term metabolic dysfunction or insulin resistance in humans; the cause is something deeper and hormonal.

Not SupportedCarbohydrates themselves do not cause diabetes or insulin resistance; processed sugar may contribute to oxidative stress, but fruit and raw honey do not.

Not SupportedFreezing organ meat and cutting it into small pieces can cause abrasion to the esophagus.

Not SupportedNutritional science often fails to consider the complex informational content of whole foods like liver.

Not SupportedWhen cooking vegetables, use tallow or butter instead of seed oils like mayonnaise.

Partially SupportedMargarine contains additives to mimic the color of butter, which naturally contains flavonoids from grass-fed cows.

Partially SupportedPaul Saladino drank a tablespoon of canola oil nightly in college.

Partially SupportedNick Bare uses olive oil for cooking potatoes or vegetables, but has increased his use of tallow and reduced olive oil consumption.

Partially SupportedSeed oils are present in processed foods such as hummus and sun-dried tomatoes.

Partially SupportedEliminating all oxidation in the human body is not desirable, as some degree of oxidation is essential for life and can trigger positive responses like gene expression.

Partially SupportedFor individuals with metabolic unwellness, minimize linoleic acid intake by avoiding olive oil and avocado oil, and prioritize fats high in stearic acid like tallow.

Partially SupportedThere are likely nutritional factors in organ meats not yet identified or included in standard nutritional databases.

Partially SupportedThe speaker intends to increase organ meat consumption, specifically liver and bull testicle.

Partially SupportedFreezing and then thawing organ meat before consumption can make it easier to swallow.

Partially SupportedLow-fat processed foods marketed in the 1980s and 1990s were often high in fructose and processed sugar.

Partially SupportedThe informational experience for the body from a tablespoon of honey is significantly more complex than from an equivalent amount of isolated sucrose.

Partially SupportedMany processed foods, including coffee creamers, can contain hidden seed oils.

Partially SupportedBarbecue restaurants using only rubs and no added oils are safer for avoiding seed oils.

Partially SupportedEliminating seed oils from home-purchased groceries is achievable and recommended.

Partially SupportedTallow consumption lowers linoleic acid intake and increases stearic acid intake.

Partially SupportedHumans have not evolved to consume seed oils or processed foods like Coca-Cola.

Partially SupportedPeptides, such as BPC-157, are small protein molecules with significant functions in the human body.

Not SupportedThe hypothesis that saturated fat intake directly correlates with heart attack risk was based on cherry-picked data from seven countries.