In mice, fructose consumption leads to problems like oxidative stress and fatty liver, whereas honey consumption does not cause these issues.

“in mice for instance with honey this is one of the most striking studies humans are not mice but the physiology is probably pretty well conserved if you give them fructose they have all sorts of problems they have oxidative stress the liver gets fatty their body goes a little haywire if you give the mouse honey it's completely different they don't have oxidative stress they don't have dna damage none of these things occur”