Paul Saladino· MD
metabolic dysfunction not a normal process in a human that is what happens when you are eating carbohydrates and your muscle is refusing them physiologic insulin resistance is you have no carbohydrates so your body is sparing glucose for other tissues of the body does that make sense makes sense so metabolic dysfunction is you are eating carbohydrates and your body's like no we don't want those because insulin is being released but all the tissues of your body are saying we're not listening to you insulin in physiological insulin resistance certain tissues are saying we're not listening to you because we're sparing glucose for the other tissues metabolic dysfunction i'm saying this twice just to make it very clear is essentially all the tissues of the human body are saying we're not listening to insulin we need an insulin levels have to go higher and higher and higher this is the progression to type 2 diabetes and the pancreas gets exhausted because the beta cells and the pancreas can't make any more insulin this is obviously oversimplified but the insulin goes higher and higher and higher because the cells of the body whether it's muscle or fat or brain or liver are saying we're not listening to you insulin we are insulin resistant