Gastric bypass surgery may improve satiety and reduce appetite by cutting branches of the vagus nerve, disrupting the signaling of dietary cannabinoids that trigger appetite and loss of satiety.

“when you cut away part of the stomach you have to cut away branches of the vagus nerve and this is a nerve that runs from the stomach to the brain and there's also thinking that this these cannabinoids that occur from the diet get into that vagus nerve and will trigger in the brain appetite and loss of satiety so when you cut those vagus nerves in the gastric bypass people are able to stop eating they don't feel quite as as hungry or they don't have this disordered satiety you know this appetite when they're eating these foods”