The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
there is a pathological condition in which there is overwhelming systemic refusal of many of the cells of our body to respond to the signals of insulin and that is what we call metabolic dysfunction and that is pathologic insulin resistance
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
all insulin resistance is not the same pathological insulin resistance metabolic dysfunction are not the same as physiologic insulin resistance in my blog i've described it as the ros is the signal from the mitochondria to the rest of the cell that it's time to get up from the dinner table and walk away it's saying we're full the insulin receptor on the surface of the cell is going to stop working and other cells can get these nutrients that is physiology
all the tissues of the human body are saying we're not listening to insulin we need an insulin levels have to go higher and higher and higher this is the progression to type 2 diabetes and the pancreas gets exhausted because the beta cells and the pancreas can't make any more insulin this is obviously oversimplified but the insulin goes higher and higher and higher because the cells of the body whether it's muscle or fat or brain or liver are saying we're not listening to you insulin we are insulin resistant
i like the term metabolic dysfunction physiologic insulin resistance is physiologic it's normal it's quote unquote healthy there's no disorder there it's what happens when you're not eating because you're in the field on deployment when i'm you know if i'm you know if i'm fasting for two days i'm gonna get physiologically insulin resistant a year and a half of a carnivore diet with no carbohydrates physiologic insulin resistance raising my fasting blood sugar right that's a normal process in a human metabolic dysfunction not a normal process in a human that is what happens when you are eating carbohydrates and your muscle is refusing them physiologic insulin resistance is you have no carbohydrates so your body is sparing glucose for other tissues of the body does that make sense makes sense so metabolic dysfunction is you are eating carbohydrates and your body's like no we don't want those because insulin is being released but all the tissues of your body are saying we're not listening to you insulin in physiological insulin resistance certain tissues are saying we're not listening to you because we're sparing glucose for the other tissues metabolic dysfunction i'm saying this twice just to make it very clear is essentially all the tissues of the human body are saying we're not listening to insulin we need an insulin levels have to go higher and higher and higher this is the progression to type 2 diabetes and the pancreas gets exhausted because the beta cells and the pancreas can't make any more insulin this is obviously oversimplified but the insulin goes higher and higher and higher because the cells of the body whether it's muscle or fat or brain or liver are saying we're not listening to you insulin we are insulin resistant so it's very important that we differentiate pathologic versus physiologic insulin resistance and that pathological insulin resistance is a state of metabolic dysfunction