Paul Saladino· MD
four hydroxy no no one of these reactive aldehyde products of linoleic acid metabolism appears to break the the division the sort of um the sort of um the hyperplasia ability of adipocytes so i'll repeat that when in people who have diabetes this is well documented i'll talk about this much more in the future we see adipocyte pathology where the adipocytes the fat cells are too big if we can expand the fat cell mass and get more fat cells that are smaller people don't get metabolic dysfunction all right this is what we saw in the sumo wrestler studies that i talked about earlier you can be fat but if you have lots of small fat cells you're not going to get inflammation you're not going to get metabolic dysfunction you're not going to get quote insulin resistance i don't like that term what prevents the fat cells from dividing what makes the fat cells too big what is causing this pathological adipocyte hypertrophy for hne is one of the things so role of physiologic levels of four hne on adipocyte biology implications for obesity and metabolic syndrome so our studies demonstrate that acute or repeated exposure of adipocytes with physiological low concentrations of hydroxynol is sufficient to provoke to promote subsequent oxidative stress impaired adipogenesis that is impaired division of the fat cells alter expression of adipocynes and increase lipolytic gene expression and increase free fatty acid release this is a really cool paper that is essentially saying that these products of linoleic acid metabolism are breaking your fat cells they are one of the causes of your fat cells getting too big and bursting essentially when they should be dividing they prevent our body from dealing with excess calories and they make us metabolically ill