Excessive intake of linoleic acid arises from its concentration and abundance in processed seed oils.

“it was really cool to hear tucker talk about cardiolipin mitochondrial membranes and yet another aspect of excess linoleic acid and omega-6 polyunsaturated fat in our diets that could be harming us in a major way”

“if we overconsume linoleic acid and the cardiolipin becomes overly enriched in linoleic acid could lead to massive problems”

“excess amounts of linoleic acid could also have pathological effects in the human body at the mitochondrial level”

“so then we need to ask is this potentially the major driver of chronic illness in humans and i think it's a very very strong candidate for this because of both its propensity to oxidize and other things it does in the mitochondria”

“linoleic acid isn't necessarily the the devil because it is essential fatty acid but what the issue is is that when we've created these seed oils we've concentrated and now we have this abundance we have too much of linoleic acid that's where the issue is”

“I think there's very good evidence to suggest that accumulation of excess amounts of omega-6 polyunsaturated fatty acids from seed oils leads to derangements in both mitochondrial membranes cell membranes nuclear membranes and those dipocytes which leads to disordered cell signaling and eventually breaks those fat cells”

“the problem with seed oils appears to be this evolutionarily inconsistent concentration of linolic acid so we did a reel on this on Instagram um that I was really proud of in order to get the amount of seed oil from corn that the average American gets per day five to seven tablespoons you would have to eat between 60 and 70 ears of corn per day damn wow you'd have to eat a pound and a half of HED sunflower seeds two and a half pounds of in the husks right so you know the baseball players will spit the sunflower seeds like this is a mountain of sunflower seeds no one could ever get through that 2 and a half pounds of sunflower seeds if you're sh if you're like husking them or whatever you know spitting them out every day every you know you're spitting the husk out 2 and a half pounds of sunflower seeds to get 5 to seven tablespoons of sunflower seed oil 2 L pounds of soybeans to get 5 to seven tablespoons of soybean oil 2 pounds of soybeans 2 pounds um and canola oil is made from a rape seed that's not even a human food and in order to make canola oil canola stands for Canadian Oil low acid so it's an acronym it wasn't even a thing they had to graft and genetically select rape seeds that were low arusc acid arusc acid is I believe it's a monounsaturated fatty acid that's been associated with myocardial liosis so heart lesions with this fatty Acid found in this seed of a plant that humans should not be eating has never been eaten by humans as a food but they made it into a food previously like all the seed oils like cotton seed oil especially that that they're making uh the chicken fingers and the fries out of adult children's machine lubricants prior to 1910 right these are not foods for the humans so there's there's no equivalent in rape seeds because humans don't eat rape seeds we don't eat cotton seeds I have no idea how many cotton seeds nobody eats cotton right you're not going to eat cotton you know there's no people didn't eat soy for the longest time it was only brought into fields to help nitrogenate the next year's crop that was it yeah so there's a massive amount so evolutionarily inconsistent amounts of linolic acid that easily get concentrated in these oils so we suddenly have this huge influx of linolic acid into our diets and it accumulates in every cell in our body and especially in our fat tissue because as humans”

“the more potent uh effect was seen with their aldehyde byproducts the products of the oxidative destruction of these unsaturated fats and yet Harvard University says don't eat saturated fat and eat canola oil did you see the FDA announced one that came out in 2019 that said you should no longer worry about dietary cholesterol it has no impact on your cardiovascular disease risk by the way the study that they based this recommendation on was not only about cholesterol it was also about saturated fat it had the same conclusions but the FDA decided to leave that recommendation unchanged they ignored that part of the study and they said yeah don't worry about cholesterol you can eat as much as you want it's the endogenous cholesterol something else happening with the cholesterol but just like just like you said these people with the with the genetic mutation they have normal levels of LDL and still develop cardiovascular disease so again LDL is probably just a symptom it's an innocent bystander something else going on under the scenes and now we have this evidence I was shocked when it's on the Wikipedia page I'll send you the the page that show that these two aldehydes of producing linoleic acid are comprised eighty percent of the plaque um and though they are very inflammatory so which basically cortisol is going to be increased and you know all kinds of other things so cortisol by the way is known to cause vascular stiffness by activating the mineralocorticoid receptor um and this is this was known as early as the 1940s when the first anti-old ocean drug known as spironolactone was invented they noticed that it was to this day he used to treat heart disease and heart failure but they noticed that basically when you give spironolactone uh their the arterial stiffness is either completely human or in some cases reverse so it's basically something through these receptors that's happening and you know cortisol is known to activate those receptors in higher amounts so when you're increasing inflammation and cortisol you're going to get your vascular stiffness indirectly um through the through the chronic inflammation and that process”

“one of those things that we accumulate that's toxic for humans is seed oils yeah you know these polyunsaturated fatty acids like linoleic acid”

“fat or adipose we accumulate that in our cell membranes in our mitochondrial membranes and overall this sets up an environment that's pro-oxidative pro-inflammatory toxic and nutrient deficient”

“excess linoleic acid is the polyunsaturated fatty acid found in seed oils that I'm very worried about for a variety of reasons. You guys can learn more about that from podcasts I've done on this channel with Georgie Dinkov, with Tucker Goodrich and Jeff Knobs. There are so many reasons that seed oils and the linoleic acid in seed oils appear to be harmful for humans. In short, accumulates in cell membranes, we can't get rid of it, probably causes increased permeability in membranes, accumulates in mitochondrial membranes in the cardiolipin, causing problems with the electron transport chain, leads to increased oxidation of LDL, increased oxidized LDL”

“our bodies can't get rid of these easily”

“the polyunsaturated fats and oils accumulate in cell membranes accumulate in a phospholipid in your mitochondria cardial lipen and break your metabolism”

“when I was listening to your podcast and looking at a lot of the references it's it's really interesting what's out there around the way that polyunsaturated fatty acids accumulate in the mitochondria and break energy production a lot of it is mechanistic studies in other species but they it it's consistent across species so there is a solid mechanism because I think that I talk about in this podcast hopefully not ad nauseum to my audience but certainly frequently about seed oils and this 18 carbon omega-6 polyon citrated fatty acid linolic acid”

“clearly demonstrated mechanisms for how these seed oils are essentially causing an epidemic of chronic illness they accumulate in our membranes but what's going on at the level of the mitochondria how are they so harmful what do we know”

“which are going into babies and accumulating in their fatty tissue accumulating in the baby's cell membranes in the mitochondrial cell membranes”

“we accumulate linolic acid we accumulate all polyunsaturated fats so the more linolic acid you eat the more it's stuffed in every cell membrane in your body whether it's the membrane of your skin the epidermis the membrane of your retina the membrane of your tongue or the membrane of your liver or the membrane of your testicles or your ovaries or your neurons it's in every single cell in your body”

“and my hypothesis is that this is an evolutionarily inappropriate consumption of linolic acid which is already most or which is already significantly oxidized in the form that you're consuming it which creates an oxidative burden but over time I think that this linolic acid populates our cell membranes and changes the way our cells function specifically what I worry about is changes in the functioning of the mitochondria at the mitochondrial membrane”

“Seed oils are corn canola safflower sunflower soybean, grape seed, etc. Evolutionarily inconsistent amounts of linoleic acid are being consumed by humans today. Things we never would have had. That linoleic acid and other polyunsaturated fats get stuck in our membranes because we don't metabolize them as humans easily.”

“That's breaking the mitochondria at the level of the membrane because you're eating excess linoleic acid which accumulates in the mitochondrial membrane breaks the electron transport chain”

“Mechanistically, I am concerned that excess linoleic acid per se, which is this 18 carbon omega6 polyunsaturated fat, which is predominant in seed oils, anywhere from 25 to 55% from canola to soybean oil or other oils. I think this mechanistically might be harmful for humans when it gets to be too much.”

“And I think that's the main problem with seed oils is that they have lots of linoleic acid. They're a very cheap easy way to just stuff your body full of linoleic acid.”

“linoleic acid will undergo peroxidation very readily and become a very harmful series of metabolites that are harmful to cell membranes and mitochondrial membranes.”