Loading…

The Simple Blueprint to Reverse Disease

PS

Paul Saladino1h 21m · 2025-01-23

Support Rate

74%

136 of 184 claims supported

Support rate

136 of 184 claims supported

136 supported48 partial / not

Claims from this content

145

Well SupportedFor general overall health, a daily creatine dose of approximately 0.1 g per kilogram of body weight is recommended.Well SupportedVegans and vegetarians may be deficient in creatine, leading to cognitive impairment, as supplementation has been shown to improve cognitive function in these groups.Well SupportedExcessive intake of linoleic acid arises from its concentration and abundance in processed seed oils.Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Not SupportedRefined, bleached, and deodorized seed oils represent an evolutionarily inappropriate and inconsistent introduction to the human diet.

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well SupportedCheck food labels to ensure all ingredients would be recognizable by a great-grandmother.

Not SupportedMethylene blue is not a beneficial intervention for improving mitochondrial function in individuals without a block in the mitochondrial electron transport chain.

Well SupportedCreatine supplementation has been shown to improve card sorting and memory tasks in creatine-deficient vegetarians.

Well SupportedIndividuals supplementing with creatine or consuming a high-meat diet should also measure cystatin C in addition to creatinine to accurately assess kidney function.

Well SupportedElevated creatinine levels in blood tests for individuals supplementing with creatine may not indicate kidney damage.

Well SupportedCreatine functions as a high-energy phosphate donor, aiding in ATP regeneration for muscular contraction.

Well SupportedCreatine is inexpensive and has no known downsides, with studies showing safety for doses up to 20-30 grams per day for over five years.

Not SupportedConsuming raw egg whites may hinder biotin utilization due to avidin binding biotin.

Well SupportedPaul Saladino prefers raw milk and will not consume non-raw milk because it has previously triggered his autoimmune disease and eczema.

Well SupportedTallow and butter are better cooking fats than olive oil due to lower monounsaturated fat, higher saturated fat, and very little linoleic acid.

Not SupportedMethylene blue can cause serotonin syndrome, which is often dismissed in patients taking SSRIs.

Well SupportedExcess linoleic acid from seed oils accumulating in mitochondrial membranes can cause proton leak, reducing ATP production and leading to metabolic dysfunction.

Well SupportedRed meat is a natural source of creatine, with varying reported amounts per pound (1-4 grams) potentially influenced by the animal's health, diet, or cooking method.

Well SupportedIn 1900, 100% of dietary oil intake was from animal fat, and in the absence of processed carbohydrates, this was not associated with chronic disease.

Well SupportedUsing incandescent bulbs, halogen bulbs, or candlelight for indoor lighting can impact health.

Well SupportedPaul Saladino uses red plastic sheets over the refrigerator light to protect his circadian rhythm at night.

Well SupportedInsulin resistance primarily occurs at the mitochondrial level, impairing ATP production.

Well SupportedDietary polyunsaturated fats, specifically omega-6 linoleic acid, accumulate in human cell membranes.

Well SupportedDiet impacts mood, brain function, and neurochemistry, as psychiatric illness is often characterized by neuroinflammation.

Well SupportedSpending extended periods outdoors and receiving significant sun exposure improves sleep quality, independent of step count.

Partially SupportedMethylene blue inhibits MAOA, increasing serotonin in the synaptic cleft.

Well SupportedPaul Saladino monitors EMF levels and avoids synthetic polyester.

Well SupportedReducing blue light exposure from devices, especially late at night, and using blue light blocking glasses can improve sleep.

Well SupportedEliminating seed oils may lead to significant health improvements, including better metabolic markers.

Well SupportedWalter Kempner's studies in the 1940s showed that a diet of white rice and sugar could cure and reverse diabetes, leading to significant weight loss.

Well SupportedReducing linoleic acid intake and consuming meat and organs can lead to significant health improvements.

Well SupportedPaul Saladino's plan includes sun exposure, ocean swimming, consuming liver, heart, and raw testicle.

Well SupportedIndividuals on keto or Paleo diets consuming less than a pound of meat daily are likely to benefit from creatine supplementation.

Well SupportedConsuming polyunsaturated fatty acids (PUFAs), specifically omega-6, leads to their incorporation into cellular membranes, which impairs efficient energy production.

Well SupportedThe human body can only tolerate approximately 2-3% of body fat as polyunsaturated fatty acids.

Well SupportedDietary recommendations include eating meat and plants, avoiding foods unrecognizable to a great-grandmother, seed oils, food dyes, and ultra-processed foods.

Well SupportedLinoleic acid, not carbohydrates, is the primary cause of metabolic dysfunction and inflammation.

Well SupportedChicken fed corn and soy is likely fed moldy grains that accumulate mold toxins, leading to elevated linoleic acid.

Well SupportedPolyunsaturated fatty acids have a half-life of approximately 680 days in the human body.

Well SupportedPigs accumulate high levels of linoleic acid regardless of diet due to down-regulated de novo lipogenesis.

Well SupportedInsulin resistance is a cellular response to impaired energy metabolism, indicating cells cannot process energy efficiently and are signaling for reduced energy intake.

Not SupportedThe quality of randomized controlled trials on seed oils is often poor, leading to a flawed argument that they are benign or beneficial for cardiovascular health.

Not SupportedDiets with less than 30% of calories from fat can negatively impact human hormones, lead to cravings and skin issues, and are difficult to sustain long-term.

Not SupportedThe US GRAS designation is a self-designation by companies to the FDA, not a thorough FDA verification of safety, and allows for approximately 10,000 food additives, compared to about 400 in Europe.

Not SupportedSeed oils are not good for humans.

Partially SupportedSeed oils may alter membrane fluidity, potentially misaligning mitochondrial electron transport complexes and preventing electron transfer necessary for ATP synthesis.

Partially SupportedAnimal studies on fructose metabolism are not directly applicable to humans due to significant biochemical differences.

Partially SupportedCooking egg whites neutralizes avidin, and biotin's heat lability in the yolk requires further investigation.

Partially SupportedMaintaining a healthy mitochondrial electron transport chain requires nutrients like CoQ10, which is found in animal meat and organs.

Partially SupportedLinoleic acid levels must be reduced to low, single-digit percentages of total fats to achieve an optimal metabolic state.

Partially SupportedHoney and fruit, when consumed in moderation, are acceptable in the diet.

Partially SupportedToxins in processed foods, such as food dyes, TBHQ, seed oils, and glyphosate, can damage mitochondria over time.

Partially SupportedA large serving of french fries cooked in prolonged heated oil can contain 1 to 1.5 milligrams of acrylene.

Well SupportedLinoleic acid is present in varying amounts in all animal fats, including meat.

Well SupportedFood companies engineer addictive products using a combination of fats, sugar, and salt.

Well SupportedHighly palatable processed foods are engineered for extreme taste and texture, making them difficult to consume in moderation.

Partially SupportedOlive and avocado oils have moderate amounts of linoleic acid, and cutting them out is recommended for achieving cellular membrane recomposition.

Not SupportedMethylene blue is a temporary 'band-aid' that does not fix underlying issues or improve overall health.

Partially SupportedReducing linoleic acid intake can accelerate cellular membrane recomposition.

Partially SupportedRefined, bleached, and deodorized seed oils were previously used as engine lubricants.

Partially SupportedFrench fries eaten on Tuesday at In-N-Out are cooked in seed oils that have been used for 6 days.

Partially SupportedEfficient conversion of potential energy from food into kinetic energy via the mitochondrial electron transport chain is crucial for metabolic health.

Partially SupportedUsing red light bulbs at night is evolutionarily appropriate as humans were not exposed to significant blue light after dark.

Partially SupportedEvolutionary evidence suggests humans historically consumed very low amounts of polyunsaturated fats.

Not SupportedIndoor artificial light, particularly from LEDs, is detrimental to health due to its lack of UV and infrared, enrichment in blue light, and flicker.

Partially SupportedMethylene blue has shown underwhelming data in studies for Alzheimer's disease.

Well SupportedThe speaker has not consumed vegetables for over five and a half years.

Not SupportedMethylene blue is not beneficial for most humans long-term and is likely overhyped.

Partially SupportedAdequate ATP production, fueled by efficient mitochondrial electron transport, is essential for all cellular processes that maintain health, including hormone production, cell membrane repair, and protein repair.

Partially SupportedThe ability of cells and mitochondria to run efficiently and produce ATP is fundamental to cellular health.

Partially SupportedHuman biology and physiology are largely unchanged over tens to hundreds of thousands of years, creating discordance with modern environments.

Well SupportedThe majority of medical issues are chronic diseases, which are largely preventable.

Not SupportedSeed oils are harmful due to refinement processes, residual chemicals, leaching from plastic, oxidation, and breakdown products when heated.

Partially SupportedWearing natural fiber clothing is preferable to synthetic materials like polyester during exercise to avoid absorbing endocrine-disrupting chemicals.

Partially SupportedPaul Saladino prefers cotton sheets and requests fragrance-free detergent for laundry when staying in Airbnbs.

Partially Supported95% of healthcare costs are for chronic condition management.

Partially SupportedLimiting linoleic acid intake and consuming animal fats like tallow and butter is a strategy to manage polyunsaturated fatty acid accumulation.

Partially SupportedThe American Heart Association began promoting polyunsaturated fat and vilifying saturated fat around the 1950s.

Well SupportedHyper-palatable, engineered foods are designed to addict consumers.

Partially SupportedOptimizing holistically across all areas of health is a valuable framework for improving well-being.

Partially SupportedHealth has always been political, a realization that became apparent during the COVID-19 pandemic.

Partially SupportedInflammation is a common underlying factor in various health conditions, often triggered by non-evolutionarily consistent foods.

Partially SupportedIn 1900, over 99% of dietary fats consumed were animal fats, with seed oils being virtually non-existent.

Partially SupportedExposure to artificial lighting in grocery stores or gyms can cause a negative physical feeling.

Partially SupportedMetabolically healthy individuals may consume chicken, pork, and pure olive oil without negative consequences.

Partially SupportedEggs, chicken, pork, avocado oil, and olive oil are significant sources of linoleic acid that can slow cellular membrane recomposition.

Partially SupportedMinimizing exposure to non-native electromagnetic fields, such as from Wi-Fi, is a prudent protective measure.

Not SupportedSeed oils are problematic due to chemical processing, plastic packaging leaching antimony, and oxidation from light and oxygen exposure.

Partially SupportedConsuming addictive foods like donuts or having 'cheat days' with them can lead to a cycle of dependence, similar to using addictive drugs.

Partially SupportedGrass-fed beef meat sticks with ingredients like grass-fed beef, apple cider vinegar, and sea salt are acceptable.

Partially SupportedGiving children junk food periodically can contribute to them developing addictive behaviors and makes parenting more difficult.

Partially SupportedWithdrawal symptoms can occur when stopping hyper-palatable, addictive foods like cookies, cakes, candies, crackers, and pizzas.

Partially SupportedUnderstanding the engineered and nefarious history of addictive processed foods can empower individuals to reclaim their health.

Partially SupportedHumans store essential polyunsaturated fats, which have a narrow therapeutic window.

Partially SupportedThe 'food not food' versus 'food versus poison' framework helps discern which foods to consume.

Partially SupportedFood quality can influence neuroinflammation, which may be a root cause of disordered eating behaviors.

Partially SupportedThe speaker's daily calorie intake is approximately 3200-3600 calories.

Partially SupportedAvoiding volatile organic compounds in homes and chemicals in food is recommended for health.

Partially SupportedFeeding monkeys a very low-fat, higher-carbohydrate diet led to membrane turnover within 30 days.

Partially SupportedSquash is classified as a fruit and is included in the speaker's diet for 2024-2025.

Partially SupportedFoods like steak and chicken, without ingredient labels, are generally preferable.

Partially SupportedMetabolically unhealthy individuals likely need to recompose cellular and mitochondrial membranes by reducing seed oil intake.

Partially SupportedThousands of people report improved health outcomes, such as reduced acne and inflammation, after eliminating seed oils from their diet.

Partially SupportedThe reverse of the anecdotal trend, where individuals feel worse after reintroducing seed oils, is rarely observed.

Partially SupportedHeating seed oils significantly increases rancidity and lipid peroxides.

Not SupportedThe diet-heart hypothesis, suggesting saturated fat raises cholesterol and causes heart attacks, is largely considered untrue and not widely accepted today.

Not SupportedEvidence does not strongly suggest saturated fat is harmful to humans.

Partially SupportedDesiccated organ supplements, containing only ingredients like tallow, vinegar, beef, and salt, are recognizable and acceptable.

Partially SupportedIncreased awareness of baseline metabolic health is important.

Partially SupportedFood and light exposure are significant factors in health and longevity.

Partially SupportedIntentional light exposure, including early morning red light therapy and spending more time outdoors, can help manage astigmatism and reduce reliance on glasses.

Not SupportedFeeding individuals with anorexia or bulimia junk food is detrimental to their recovery.

Partially SupportedEnergy toxicity can result from inefficient energy utilization in the electron transport chain, not solely from high caloric intake.

Not SupportedLong-term trials examining seed oil consumption have shown a significant spike in cancer rates in the experimental group fed seed oils compared to the saturated fat control group.

Partially SupportedThe 'light diet' and quantum biology suggest light significantly impacts mitochondria and cellular health.

Not SupportedThe 'calories in, calories out' model is a fallacy because food quality impacts energy generation and toxins can damage mitochondria.

Not SupportedModernized individuals consuming seed oils alongside refined flour and sugar show a divergence in health compared to less modernized counterparts.

Not SupportedThe claim that it takes four and a half years to detox from seed oils is incorrect.

Partially SupportedTallow is included in the speaker's diet.

Not SupportedGiving individuals with disordered eating advice like 'all foods fit' can lead to addiction to junk food and fuel underlying neuroinflammation.

Partially SupportedHumans do not fare well when they move away from natural fabrics and natural environments.

Not SupportedCultures that consume seed oils generally do not exhibit good health, while cultures that avoid them often display exemplary health.

Not SupportedPaul Saladino took methylene blue for a month and noticed no effects, leading him to discontinue its use, possibly because he has healthy mitochondria.

Partially SupportedA diet high in processed foods and seed oils can diminish critical thinking capacity via inflammation.

Partially SupportedNutritional interventions can affect human intelligence.

Partially SupportedThe addictive properties of hyper-palatable foods like donuts are comparable to those of drugs like alcohol, heroin, or meth, suggesting a need for similar recovery parallels.

Not SupportedThe 'calories in, calories out' model for weight loss oversimplifies the issue by ignoring the addictive and habit-forming nature of many processed foods.

Partially SupportedIndividuals with a tendency towards addictive eating may need a strict 'food not food' mental framework to avoid overconsumption.

Not SupportedRefined seed oils' historical use as engine lubricant and their correlation with chronic illness suggests a need for careful study.

Partially SupportedHigh-quality foods like steak, eggs, dairy, fruit, and vegetables may reduce obsessive and disordered thinking in individuals with anorexia or bulimia.

Partially SupportedFeeding monkeys a very low-fat, higher-carbohydrate diet may accelerate seed oil detoxification.

Partially SupportedRemoving hyper-palatable and addictive processed foods completely could lead to an overnight improvement in metabolic health.

Partially SupportedConsuming red meat, tallow, and butter (1-2% linoleic acid) with fruit and vegetables can rapidly improve metabolic health by inducing fast recomposition of cellular membranes.

Partially SupportedPaul Saladino stood outside a conference in Phoenix with his shirt off to get sunlight on his body.

Partially SupportedA low linoleic acid diet experiment should involve checking fasting insulin at the start and minimizing linoleic acid intake from sources like olive oil, avocado oil, egg yolks, chicken, and pork.

Partially SupportedChallenging deeply held beliefs can negatively impact neurobiology and neurotransmitters.

Partially SupportedFoods like steak and raw milk should not inhibit the conversion of potential energy into kinetic energy, unlike junk food.

Partially SupportedAstigmatism was identified after increased screen time, prompting intentional light diet management.

Not SupportedMany Western medical diagnoses are manifestations of a few core issues like inflammation.

Partially SupportedEating foods unrecognizable to one's great-grandmother may be a root cause of health problems.

Partially SupportedEating meat and plants and avoiding unrecognizable foods can improve health and reduce healthcare costs.

Partially SupportedRemoving seed oils from processed foods can lead to a reduction in overall processed food intake.

Partially SupportedIn the early 1900s, pigs fed coconut oil became leaner with upregulated metabolic rates, while pigs fed soybean oil became fatter.

Partially SupportedThe ability to hold and evaluate conflicting ideas objectively before changing one's mind represents evolved thinking.

Partially SupportedPaul Saladino exclusively eats red meat and animal fats like butter and tallow, avoiding eggs, olive oil, avocado oil, chicken, and pork, to stay lean at 47 without lifting weights.