Andrew Huberman· PhD
Any curious should know that it has (weak) MAO inhibitory activity… net effect increased serotonin.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Any curious should know that it has (weak) MAO inhibitory activity… net effect increased serotonin.
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it's an MAOI inhibitor so it's a monoamine oxidase inhibitor MAO inhibitor uh which is going to have some sort of let's say psychological effects which make it very hard to tell if what you're feeling on methylene blue is related to increased energy metabolism or just different neurotransmitters in your brain
it's an MAOI inhibitor so it's a monoamine oxidase Inhibitors MAO inhibitor
So the first thing to consider here is what this molecule actually does in your body. It does a couple of things. One of the more important things that it does in your body is inhibit an enzyme called monoamine oxidase A primarily. It's a very strong inhibitor of MAOA which breaks down monoamine molecules like serotonin and it also inhibits monoamine oxidase B but to a lesser extent.
By inhibiting MAOA in a significant way, you are increasing the amount of serotonin, a neurotransmitter in the synaptic cleft between the neurons because that's where it gets broken down by these monoamine oxidase enzymes.