Methylene blue can cause serotonin syndrome, which is often dismissed in patients taking SSRIs.

“if taken in to have a dose you can actually get serotonin syndrome”

“methylene blue can cause serotonin syndrome so I think if people are going to if people want to consider using it I would number one make sure you get a very reputable source of it make sure you're consuming it in a way that makes sense I mean it can stain your teeth blue and all sorts of stuff so your urine blue your tongue blue but um people will do IV infusions of methylene blue so yeah no that's I've seen people kind of hooked up to IVs with a meth a bag of methylene blue do they turn blue and they I hope not Smurf Smurf but it is a medically approved treatment um and I think it can be done in safe ways again it's off patent nobody's going to stand make any money off of doing large welld designed Trials of methylene blue um but I'm really interested in it as uh this as it has these properties in addition to just being this electron acceptor and donor um there's some evidence that it may improve mitochondial biogenesis that it has anti-inflammatory effects and and that it can do other things that that may be beneficial interesting very interesting in fact before moving on to some more clinical questions we've been going deep into the science and some Public Health uh thoughts and Reflections and um ideas there's a supplement called uthan a that people seem really excited about for improving mitochondrial function um I'm not super familiar with the literature um but co-enzyme q12 uthan a we're starting to hear more about these these sorts of things sold over the counter do you have any thoughts on those there's a company timeline that puts out this product and to their credit they have actually done some pretty well-designed robust randomized controlled Trials of urethan a they've primarily focused on muscle health and aging and so actually have reasonably good data published in reasonably good journals um documenting that EUR aithan a when given to elderly people people you know people over 55 65 um that it can improve muscle mass and performance within I think like eight weeks um uh and and that that has overarching metabolic benefits that have you know in terms of biomarkers that have been associated with um slowing of the aging process so um so urethan a I think is definitely a supplement if among all of the supplements that should be considered if people are looking for something to take I'm going to repeat my myself before you take urethan a I've said this to the chief scientific officer of the company um when I was talking with him about this and I said but you know that diet and exercise are much more he said yeah yeah yeah of course like harder to sell people have to do the diet and exercise and everything else but then this could give them an advantage and I don't deny that at all I think it it may very well give people an advantage and again the way that I think about it it's not that diet and exercise are going to cure everybody because they won't cure everybody some people are really ill and the way that I think about that is that their mitochondria their metabolic processes are really disrupted they are severely disregulated and that quote unquote healthy diet and good exercise and good sleep and good relationships are phenomenal prevention strategy for some people they can be a phenomenal treatment strategy but I think on average that applies to people with mild to moderate mental health or metabolic health conditions that once once people get into the severe category severe heart failure severe you know mental health condition like schizophrenia bipolar disorder crippling depression my sense is just a clean diet and good sleep and good exercise is not going to be sufficient and then we do need to start thinking about can we use this supplement or this methylene blue infusion or even neuros stimulation which is can stimulate mitochondria and stimulate neuroplasticity things like transcranial magnetic stimulation yes which is done non-invasively right it is noninvasive and so can we use those types of strategies to try to improve someone's mental health and we've got plenty of evidence that you know especially with TMS that it can be very helpful for some people but again is not a Panacea none of these things are a Panacea and although I just said that none of these things are a Panacea so if you're you know people one of the biggest criticis I get is Dr Palmer you have not given me the recipe to cure my crippling ex disorder and it's like well I I'm trying to teach you the strategies and the science so that you can put together your own treatment plan I am not here to sell any one thing as this is the Panacea to cure all mental illness the ketogenic diet can be lifechanging life-saving it can be nothing short of miraculous for some people but it is not a Panacea I've seen people do ketogenic diets and not get cured not get remission and so I'm always looking for what else what else can we do how else can we use this model to”

“because I because methylene blue as I understand has some Mao activity the um can adjust some of the enzymes that in turn adjust levels of Serotonin um which is why I haven't taken it I've just been cautious about I don't really want to boost my serotonin”

“Med review: Do not take methylene blue with any antidepressants (SSRIs, SNRIs, MAOIs), or other serotonergic supplements/herbs or to linezolid (an antibiotic).”

“which may disrupt your serotonin and ATP production.”

“which is why you can't use it with anything that's serotonergic”