The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
studies from the 1940s I think Walter Kempner I think the the white rice study where he fed people white rice and sugar and they lost hundreds of pounds you know the diabetes is cured and reversed so that they can eat you know more a more a more varied diet when they're done so like giving people pure white rice and sugar caused a resolution of diabetes
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in the 1930s and 40s there was something called the rice diet and people ate white rice and table sugar they had a very low fat diet and their diabetes reversed so their diet yeah their diet was almost entirely carbohydrates and most of it was table sugar yeah and they had very low fat and their diabetes reversed
he fed them white rice and pure cane sugar and they lost weight and they become insulin sensitive and then after liberalization of the diet they remain healthy and their diabetes does not return
he took people with diabetes and obesity and put them on a 2,000 calorie diet he had over a hundred people in the study that he followed for up 22 months and he put them on a 2,000 calorie diet so not not terribly calorie restricted but it was almost entirely fruit fruit juice white refined sugar and white rice very very low fat very low protein so he put them on a very low fat diet and very high carbohydrate diet similar to the monkeys and he didn't look to see what was going on with membrane composition but these people the majority of these people not for everyone but the majority of the people in his study significantly reversed diabetes quickly and they lost in some cases hundreds of pounds
in the 1950s and 1960s he took diabetics and he gave them a diet of processed white sugar and rice a 20 ,000 calorie very lowfat diet of almost white rice and white sugar and their diabetes got better It reversed wow but in order to do this he had to lock them in a hospital right and there's controversy because apparently he had to like whip them to get them like you cannot keep a human on this diet I'm not advocating for humans being whipped in metabolic WS but it's an interesting study that would never be repeated today right right so it's a very it's an example of a very lowfat diet in humans and the pictures in his studies are remark it's like a very rotund man and he's rail thin after 6 months really and the diabetes completely reverses and even when Walter reversed or liberalized their diet the the diabetes did not come back so there are now multiple data points of very lowfat diets leading to resolution of metabolic dysfunction and I think what's going on here is accelerated membrane remodeling