Excess linoleic acid from seed oils accumulating in mitochondrial membranes can cause proton leak, reducing ATP production and leading to metabolic dysfunction.

“all of these linoleic acid molecules are going to get incorporated into your cell membranes into the mitochondrial membranes into cardiolypen in the mitochondrial membrane and that's going to be a big problem so this i think is at the root of many of the issues that people find with mitochondrial dysfunction long-term diabetes insulin resistance basically the problems with breaking fat cells i think have to do with excess cinnamonic acid”

“we talked about the insulin resistance driver with the seed oils at the level of the fat cells and hne you can also look at seed oils being incorporated into cardiolipan at the level of mitochondria”

“hey look uh seed oils are not benign and the accumulation of excess linic acid in the mitochondrial membranes of muscles or any tissue in the body probably also contributes to worsening insulin resistance as we age”

“you said the big c word you've talked about insulin resistance like what do you think some of the biggest damages that are caused by sedol actually are at a mechanistic or cellular level this is where things get really interesting I think that it has to do with membranes”

“Seed oils are corn canola safflower sunflower soybean, grape seed, etc. Evolutionarily inconsistent amounts of linoleic acid are being consumed by humans today.”

“And there's evidence from animal models and cell culture that when you have excess linoleic acid from seed oils in the mitochondrial membrane, you get proton leak. And if you're the whole point of the electron transport chain is to create a gradient that the protons can flow down to make ATP. If you are leaking protons across down the gradient, you are making less ATP.”