How to Reverse Insulin Resistance (Not Keto)

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Paul Saladino7m · 2025-04-20

Claims Made

26

Claims Supported

22

Support Rate

85%

Support rate

22 of 26 claims supported

22 supported4 partial / not

Claims from this content

22

Well SupportedExcessive intake of linoleic acid arises from its concentration and abundance in processed seed oils.Well SupportedExcess linoleic acid from seed oils accumulating in mitochondrial membranes can cause proton leak, reducing ATP production and leading to metabolic dysfunction.Well SupportedSaturated fat is protective against lipopolysaccharide (LPS) by facilitating its transport to the liver for detoxification.Well SupportedHigher concentrations of polyunsaturated fats in the mitochondrial membrane increase proton leak across the inner mitochondrial space, compromising the energy gradient.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Excessive carbohydrate restriction can lead to stress, carbohydrate fear, electrolyte issues, sleep disturbances, palpitations, and declining sex hormones.

Partially SupportedMetabolically unwell individuals experience greater blood sugar spikes from fruits and honey and should limit these foods.

Partially SupportedGlyphosate's mechanism of action involves oxidative stress and mitochondrial dysfunction.

Not SupportedCarbohydrates, including grain-based ones, are not the primary problem for human health and do not necessarily create insulin resistance or metabolic dysfunction.

Partially SupportedFixing one's diet is a foundational step for health.

Partially SupportedInappropriate consumption of seed oils and processed foods increases gut lipopolysaccharide, contributing to metabolic dysfunction.

Partially SupportedRemoving seed oils from the diet can help reverse the progression towards metabolic dysfunction.

Partially SupportedExcess fatty acids disrupt the structure of mitochondrial membranes, including cristae and folds.

Partially SupportedAdding carbohydrates to the diet can improve metabolic markers like lowering fasting blood sugar.

Not SupportedEliminating fruits and honey from the diet is a bad idea, as some studies show benefits from honey consumption.

Partially SupportedElevated lipopolysaccharide (LPS) levels from gut dysbiosis and endotoxemia are detrimental to glycolytic oxidative phosphorylation metabolism.

Partially SupportedExcess linoleic acid from seed oils and lipopolysaccharide from a disordered gut are the two primary factors that disrupt mitochondrial energy production.

Partially SupportedLimiting carbohydrates too much in metabolically unwell individuals can lead to increased stress hormones, thyroid issues, and electrolyte imbalances.

Partially SupportedOvergrowth of certain bacteria in the gut leads to lipopolysaccharide (LPS) in the human body, which can disrupt energy metabolism.

Not SupportedStrict carnivore diets can negatively impact metabolic health, leading to electrolyte imbalances and lower fasting blood sugar.

Partially SupportedMechanistic studies are valuable for generating hypotheses about health and physiology.

Not SupportedFruit consumption did not cause obesity or metabolic dysfunction in overweight or obese individuals.

Partially SupportedConsuming foods with evolutionarily inconsistent fatty acid profiles may negatively impact energy metabolism.