Higher concentrations of polyunsaturated fats in the mitochondrial membrane increase proton leak across the inner mitochondrial space, compromising the energy gradient.

“part of this is because within each species there's a range that's kind of a set point but we can change our the saturation of our membranes based on our diet as well within that set point so this is this is absolutely huge this is a massive massive effect this inefficiency of energy production in terms of health aging and lifespan and so I would say this is the top Factor when it comes to the polyunsaturated fats and how they're affecting us and that doesn't even also consider all of the oxidative stress that goes on inside the mitochondria when they when these fats are incorporated into the membranes which just makes it that much worse because then the mitochondria there are incredibly susceptible to damage the membrane is incredibly susceptible to damage and that oxidative stress also impairs respiration and impairs our ability for uh producing energy”

“and that doesn't even also consider all of the oxidative stress that goes on inside the mitochondria when they're when these fats are incorporated into the membranes which just makes it that much worse because then the mitochondria there are incredibly susceptible to damage the membrane is incredibly susceptible to damage and that oxidative stress also impairs respiration and impairs our ability for uh producing energy”

“the more polyunsaturated fats there are in the mitochondrial membrane the more proton leak there is across the inner mitochondrial space and the matrix and that is what that gradient is our battery that is our cellular battery and if you break that battery if you break that difference in in charge you don't make energy as well”

“That linoleic acid and other polyunsaturated fats get stuck in our membranes because we don't metabolize them as humans easily. some we do those specifically we don't metabolize we don't get rid of them and that there's evidence I mean there's again you can't do randomized control trials on this you have to look at cell culture you have to look at in vitro studies but the more polyunsaturated fats there are in the mitochondrial membrane the more proton leak there is across the inner mitochondrial space and the matrix and that is what that gradient is our battery that is”