Higher concentrations of polyunsaturated fats in the mitochondrial membrane increase proton leak across the inner mitochondrial space, compromising the energy gradient.

“this evidence that polyunsaturated fats in those membranes makes that battery leaky is so profound it's like wait you're making a battery to run your life and the linolic acid makes the battery crappy it just makes it Le the the polarity of the battery which what you need to carry the energy because at the end of the electron transer chain those protons move that gradient you've created moves through this little motor this microscopic motor called atpa and it makes ATP and if there's not as many protons move through that you make less ATP and so this idea that you are leaking literally leaking proteins and this has been shown in multiple studies this proton leak at like a quantum physics level they can measure this there's Quantum leak of these protons with more linolic acid in these membranes that to me is just freaking profound that you're basically making a really crappy battery you know you're just making bad the engine is bad like at this point the metaphor breaks down and I'm mixing batteries and engines but you guys get the idea that like basically if you want to be healthy you want to make ATP and you're G to make less ATP because you have less of a gradient with the with the protons because you're leaking the protons”

“and that doesn't even also consider all of the oxidative stress that goes on inside the mitochondria when they're when these fats are incorporated into the membranes which just makes it that much worse because then the mitochondria there are incredibly susceptible to damage the membrane is incredibly susceptible to damage and that oxidative stress also impairs respiration and impairs our ability for uh producing energy”

“the more polyunsaturated fats there are in the mitochondrial membrane the more proton leak there is across the inner mitochondrial space and the matrix and that is what that gradient is our battery that is our cellular battery and if you break that battery if you break that difference in in charge you don't make energy as well”

“That linoleic acid and other polyunsaturated fats get stuck in our membranes because we don't metabolize them as humans easily. some we do those specifically we don't metabolize we don't get rid of them and that there's evidence I mean there's again you can't do randomized control trials on this you have to look at cell culture you have to look at in vitro studies but the more polyunsaturated fats there are in the mitochondrial membrane the more proton leak there is across the inner mitochondrial space and the matrix and that is what that gradient is our battery that is”