Animal studies on fructose metabolism are not directly applicable to humans due to significant biochemical differences.

“so many of the studies fructose that say that it's harmful for you are animal studies isolated fructose feeding studies which don't really you know recapitulate what's happening in actual human biology”

“if you look at someone who's trying to make a case that fructose is harmful invariably they will site studies in animals who don't have the same biochemistry they do much higher rates of denova lipogenesis when they presented with fructose meaning if you give fructose to a rat it's making much more of that into body fat than than we do as a human we do 1% you give a human 1% of fructose goes to Fat via denova lipogenesis most of it goes to glucose it goes to um you know glycogen it goes to lactate like glucose I mean fructose doesn't turn into fat in humans anywhere near like it does in animals so you can't look at animal studies for fructose metabolism because it's completely different right it's completely different”