The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the best evidence we have regarding the pharmacokinetics of polyunsaturated fatty acids suggest that their Half-Life is 680 days well four and a half half-lives to get rid of something if you've taken pharmacology that's a pretty significant amount of time that sounds like about two to five years that a molecule of linoleic acid that you would get from anywhere and you're going to get more of from aceto oil could get stuck in your cell membrane
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the canonical thinking is that it takes four and a half years to fully recycle your membranes based on some pharmokinetic studies with polyunsaturated fats and that may be the case if you don't change specific things about your diet but I think that there are ways to do this more quickly
I think that there are ways to do this more quickly and there are two really interesting studies that I've come across recently that make me think this is possible much more quickly and it requires very intentional intervention in our diet as humans
if a human wanted to accelerate the remodeling of your membranes you could potentially eat a lower fat diet for 30 60 90 days understanding that a lowfat diet is not super sustainable for humans