Paul Saladino· MD
an elevated ldl in the absence of metabolic dysfunction is not problematic
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
an elevated ldl in the absence of metabolic dysfunction is not problematic
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so in this condition in this situation is ldl really going to be the same player in atherosclerosis that it appears to be in someone with diabetes or metabolic dyslipidemia i would argue no it's not the context matters it is the ultimate determining factor
i believe i don't believe ldl is harmful for humans if you're metabolically healthy
in humans who are metabolically healthy levels of LDL cholesterol are horribly bad at predicting cardiovascular disease
Multiple studies show in people that are metabolically healthy that the relationship between cholesterol and cardiovascular disease is massively attenuated or not even present.