Physiological insulin resistance is a normal and protective state in a ketogenic state.

“physiologic insulin resistance is physiologic it's normal it's quote unquote healthy there's no disorder there it's what happens when you're not eating because you're in the field on deployment when i'm you know if i'm you know if i'm fasting for two days i'm gonna get physiologically insulin resistant a year and a half of a carnivore diet with no carbohydrates physiologic insulin resistance raising my fasting blood sugar right that's a normal process in a human”

“when you are in a ketogenic state your adipocytes are releasing palmitate they are signaling to the periphery that they should become insulin resistant this is physiologic insulin resistance this is glucose sparing this is how your body stays alive when you are surviving in the wilderness when you are doing your fast”

“this is a physiologic adaptation to starvation or ketogenic diets or low carbohydrate diets that allows us to spare glucose for red blood cells testicles adrenals brain Etc so it's normal physiology to have physiologic insulin resistance”

“when you are in a ketogenic State when you are fasting you will also have higher levels of non-sterified fatty acids because the fat cells will be releasing those free fatty acids into the blood and you do get something called physiologic insulin resistance at the level of the muscles primarily but also so that can happen at the level of the liver but the difference is that insulin levels are low in that state and if you return carbohydrates to the system you will regain insulin sensitivity”