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Animal-Based Vs Keto, A friendly debate with Thomas DeLauer

PS

Paul Saladino1h 19m · 2022-07-26

Support Rate

76%

128 of 168 claims supported

Support rate

128 of 168 claims supported

128 supported40 partial / not

Claims from this content

148

Well SupportedDiabetic patients consuming high amounts of honey (up to 180+ grams/day) in a study lost weight and became more insulin sensitive, despite an increase in hemoglobin A1c.Well SupportedRiboflavin is crucial for methylation reactions, particularly for individuals with MTHFR polymorphisms, and can help a 'broken' MTHFR enzyme function optimally.Well SupportedHeart and Soil's 'Skin Hair and Nails' product, containing trachea and scapular cartilage, liver, and bone marrow, is beneficial for skin, hair, nails, bones, and joints.Well SupportedConsuming connective tissue provides glycine and helps maintain a healthy methionine-to-glycine ratio.Well SupportedAn excess of methionine without sufficient glycine can be harmful.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well SupportedInsulin plays a role in renal sodium transport, leading to sodium retention.

Well SupportedRestricting methionine for longevity is unnecessary; providing sufficient glycine is an alternative approach.

Well SupportedThe free testosterone to cortisol ratio is a useful marker for training stress and requires a moderately high carbohydrate intake for validity.

Well SupportedOrgan meats are crucial for filling nutritional gaps not met by muscle meat or plants and are historically treasured for their nutrient density.

Well SupportedPure fructose or processed sugars like high-fructose corn syrup should not be conflated with whole-food carbohydrate sources such as fruit or honey.

Not SupportedHigh doses (4g or more per day) of omega-3 supplementation from fish oil are associated with an increased risk of atrial fibrillation and cardiac arrhythmia.

Well SupportedIn hunter-gatherer societies, meat and organs consumed nose-to-tail with fat are central to life and sustain individuals due to their nutrient density.

Well SupportedLinoleic acid in seed oils increases anandamide and 2-AG in the brain, which binds to CB1 receptors and induces hunger.

Well SupportedTo obtain health benefits from honey, it should be raw, filtered, organic, and tested for glyphosate contamination.

Well SupportedProcessing honey diminishes its beneficial properties, such as nitric oxide precursors and potential testosterone-boosting effects.

Well SupportedInsulin signaling is required to keep sex hormone binding globulin levels down, increasing free hormones.

Not SupportedThe 'calories in, calories out' model is an oversimplification.

Well SupportedCarbohydrates do not inherently cause insulin resistance, and fasting insulin levels can be low even with high carbohydrate intake.

Well SupportedDifferent types of fats affect human physiology differently, indicating that not all calories are equal.

Well SupportedOrgan meats, including liver, heart, kidney, pancreas, and spleen, are nutritionally dense and were historically consumed immediately after an animal was killed.

Well SupportedExcess omega-6s can inhibit the conversion of alpha-linolenic acid to EPA and DHA.

Well SupportedPhysiologically normal glucose regulation involves a normal increase in glucose, especially after consuming carbohydrates, followed by a quick return to normal levels.

Partially SupportedPaul Saladino's breakfast includes 12-14 ounces of goat's milk with 5+ tablespoons of honey, followed by steak, raw liver, and heart.

Well SupportedThe American population consumes 7-10% of its calories from linoleic acid, which is more than twice the amount consumed by indigenous hunter-gatherer populations.

Well SupportedThe relevance of glycemic index (GI) and glycemic load (GL) for body weight, diabetes, and cardiovascular disease has essentially no predictive value.

Well SupportedWhen fat cells become hypertrophic, they release inflammatory mediators and experience macrophage infiltration, which is associated with insulin resistance and vascular endothelial dysfunction.

Well SupportedPhysiological insulin resistance is a normal and protective state in a ketogenic state.

Well SupportedSeed oils may disrupt satiety by interfering with cannabinoid receptors and the hypothalamus.

Well SupportedMaintaining insulin sensitivity is critical for individuals, and checking fasting insulin levels is important for assessing metabolic health.

Partially SupportedPhysiologic insulin resistance in a low-carbohydrate state is a normal human physiological response distinct from pathological insulin resistance.

Not SupportedKetogenic diets are not optimal for long-term human health, except for specific conditions or short-term appetite reduction.

Well SupportedPostprandial insulin spikes from carbohydrates can lead to beneficial changes in sex hormone binding globulin and glutathione.

Well SupportedTestosterone levels should be tested within two to three hours of waking, as they are highest in the morning.

Not SupportedStrictly controlling blood sugar to a peak below 110 mg/dL or an average of 85 mg/dL with a standard deviation of 10 mg/dL can be detrimental.

Well SupportedConsuming sugar in whole foods like honey, fruit, or fruit juice does not increase endotoxin levels, lead to insulin resistance, or cause inflammation.

Well SupportedAnimal models suggest substituting honey for refined carbohydrates protects rats from hypertriglyceridemic and peroxidative effects of fructose.

Well SupportedElevated blood sugar two hours after a meal may indicate an issue, especially for individuals without a history of low-carb diets or fasting.

Well SupportedGlycine content in beef cuts like chuck, flank, neck, plate, rib, and rump ranges from 6.26% to 8.57%, while methionine levels range from 1.88% to 2.46%.

Well SupportedIncreased free fatty acids during ketosis or fasting represent a physiological insulin resistance response that can raise cortisol.

Well SupportedFructose in whole foods like honey and fruit does not cause insulin resistance or metabolic harm.

Well SupportedA significant decline in testosterone in men may indicate excessive stress from practices like fasting.

Partially SupportedFat cells can signal muscles to become insulin resistant through the release of lipokines, a phenomenon that can occur during fasting states.

Partially SupportedIncluding carbohydrates, specifically fruit and honey, in the diet improves metabolic health and well-being after a zero-fiber diet.

Well SupportedRelying solely on blood glucose management for health will likely yield poor long-term outcomes.

Partially SupportedRiboflavin (Vitamin B1) is critical for methylation, particularly for the MTHFR enzyme, and is poorly obtained from plants and muscle meat.

Not SupportedPolyunsaturated fats in seed oils can abrogate the normal physiological insulin resistance of a ketogenic diet.

Partially SupportedMonitoring morning testosterone or cortisol levels can serve as a metric of stress.

Well SupportedFasting requires meeting protein and other nutritional needs to avoid negative consequences.

Partially SupportedJunk food, particularly seed oils, may stimulate cannabinoid receptors, leading to satiety disorders and overeating.

Partially SupportedAn animal-based diet of nutrient-rich foods promotes satiety and can lead to weight loss without negative consequences.

Partially SupportedDietary changes to a carnivore or animal-based diet have been observed to significantly improve various skin conditions.

Partially SupportedCalories from different sources like honey, sucrose, Coca-Cola, seed oils, and animal fats are not metabolically equivalent.

Partially SupportedKefir is a beneficial fermented dairy product.

Partially SupportedFish consumption is associated with increased rates of melanoma due to potential contamination.

Not SupportedFasting should not be used as a license to reduce movement, as this can lead to muscle catabolism.

Well SupportedSAMe administration can rescue the effects of methionine restriction on the TOR pathway.

Partially SupportedSupplements containing less than half an ounce of liver per day can provide a small but effective dose.

Partially SupportedMetabolic dysfunction involves hypertrophied fat cells that are unable to divide.

Partially SupportedTo support glutathione production, individuals should ensure adequate glycine and methionine intake and consume organ meats and connective tissue.

Partially SupportedAn average blood sugar over 90 days of 108 mg/dL can correspond to post-meal glucose levels of 120-140 mg/dL without being a cause for concern.

Partially SupportedConsuming fat and chewy bits from steak provides collagen-rich pieces that are higher in glycine.

Partially SupportedOptimal blood glucose reference ranges include a ceiling of 140-155 mg/dL, a quick return to baseline, a small area under the curve, low glycemic variability, low fasting blood glucose, and fasting insulin ideally below 5, preferably below 3 micro IU/mL.

Partially SupportedHoney has shown protective effects against cardiovascular disease, oral mucositis, and cavities.

Partially SupportedFocusing on food quality and avoiding metabolism-damaging foods can lead to weight loss and metabolic health.

Partially SupportedEating liver and heart is part of a nutrient-rich diet that avoids processed foods, seed oils, and processed sugars.

Partially SupportedConsuming collagenous tissues in addition to muscle meats may help balance the methionine and glycine ratio.

Not SupportedMinimizing insulin area under the curve is not the wrong approach and does not cause metabolic dysfunction or insulin resistance.

Partially SupportedConsuming a couple of tablespoons of honey can lead to satiety for several hours.

Not SupportedThe demonization of insulin is problematic, as insulin signaling is necessary for various physiological functions.

Partially SupportedTraining intensely in a deep ketogenic state can provide a similar hormetic stressor as extreme caloric deficits.

Not SupportedAn obsession with blood glucose can lead to extreme dietary approaches.

Partially SupportedIntroducing carbohydrates or fruit after periods of ketosis can enhance metabolic flexibility and provide dual benefits.

Partially SupportedThe speaker's current health metrics include very low inflammation (hs-CRP 0.5), low fasting insulin, and IGF-1 half a standard deviation below the mean.

Well SupportedFour weeks of a 16-8 intermittent fasting window has been shown in studies to cause a decline in testosterone for males.

Well SupportedEating within an earlier time-restricted eating (eTRF) window may be marginally better than simply skipping breakfast.

Partially SupportedInsulin-induced insulin resistance is extremely rare in humans, and strict control of absolute insulin levels or insulin area under the curve is unnecessary.

Partially SupportedAlmonds contain cyanide in their natural state and require hybridization to be consumed.

Well SupportedPalmitate causes insulin resistance in cell cultures by converting into ceramides, while monounsaturated and polyunsaturated fatty acids do not.

Partially SupportedReducing omega-6 intake allows the body to produce sufficient omega-3s, and a small amount of omega-3 is ideal.

Partially SupportedNutritional studies should be conducted ad libitum, as this better mimics natural eating behaviors than forcing overeating.

Partially SupportedThomas DeLauer shifts his fasting windows around, experiencing fasting benefits at different times of the day without a structured eating window.

Well SupportedEating more calories earlier in the day and tapering them off with a lighter dinner may improve sleep quality and function.

Partially SupportedA ketogenic state can serve as a hormetic stressor, comparable to caloric restriction or training in a deprived state.

Partially SupportedOvereating, regardless of macronutrient source, is the primary problem leading to issues like hepatic triglycerides.

Well SupportedMovement is critical and should be maintained even when practicing intermittent fasting.

Partially SupportedThe speaker prioritizes optimizing sleep and avoids eating within three hours of going to sleep.

Partially SupportedDisordered brain signaling, primarily related to seed oils and likely processed sugar, is the reason most people overeat.

Not SupportedMany in the longevity community who advocate extreme fasting or protein restriction may lack lean muscle mass and have compromised hormones.

Partially SupportedPeriods of ketosis, histone deacetylase inhibition, and being in a ketogenic state are beneficial for humans and mammals.

Partially SupportedIncorporating carbohydrates into a ketogenic diet can initially cause glucose spikes, but fasting glucose levels may decrease with consistent carbohydrate intake.

Partially SupportedSwitching between fat and glucose metabolism requires an adjustment period, analogous to getting rust off railroad tracks.

Not SupportedFasting practices that impinge on sleep quality, such as eating within a narrow window close to bedtime, should be avoided.

Not SupportedExcessive fasting, intermittent fasting, or ketogenic states can lead to negative outcomes and sacrifice performance.

Partially SupportedExcessive intake of linoleic acid can lead to fat cell breakdown and negative health consequences, though this is reversible.

Partially SupportedIn a ketogenic study, individuals became more insulin sensitive when given seed oils, indicating glucose was going to inappropriate places.

Partially SupportedDrinking ketone esters, ketone salts, or achieving nutritional ketosis in diabetics lowers the hunger hormone ghrelin.

Partially SupportedFat cells release lipokines that signal muscles to become insulin resistant.

Partially SupportedKeto diets require responsible implementation with awareness of potential long-term negative effects.

Partially SupportedOmega-6 fatty acids from meat are not inherently problematic, but the absolute amount consumed is the issue.

Partially SupportedKetones are a normal and protective survival mechanism in mammals, including humans.

Not SupportedThe omega-3 to omega-6 ratio is a red herring and distracts from the core issue of excess omega-6 consumption.

Partially SupportedLow riboflavin intake can lead to elevated homocysteine levels, impacting methylation, neurotransmitter function, and detoxification.

Partially SupportedChewy steaks likely have more glycine due to higher collagenous connective tissue content compared to tender steaks.

Partially SupportedNuts and seeds have lower caloric density and require more effort to process compared to other food sources.

Partially SupportedExcess seed oil consumption is a significant problem due to rancidity and signaling processes.

Partially SupportedHigher methionine levels are associated with problems, and methionine is rich in muscle meat.

Partially SupportedEgg yolks are nutritionally close to cream, with a slight preference for cream.

Partially SupportedA ketogenic diet or state of ketosis has benefits for intractable epilepsy.

Partially SupportedBlocking cannabinoid receptors reduces hunger, while activating them increases hunger.

Partially SupportedControlling appetite is crucial for sustainable weight loss, which is a major health challenge in Western populations.

Not SupportedEating consistently after sunset may negatively impact circadian rhythm markers and sleep.

Not SupportedWild-caught salmon may not be healthier than steak due to potential contamination in fish and the nutritional value of fat from grass-fed animals.

Not SupportedDiets that do not control hunger are ineffective long-term due to hormonal disruption.

Partially SupportedMetabolic pathways tend to maintain their current state, with intermediates from one pathway inhibiting another.

Partially SupportedProcessing nuts like acorns and pine nuts is labor-intensive and requires detoxification or specialized collection methods.

Partially SupportedKetogenic diets can be used as a hormetic stressor, but individuals should monitor their free testosterone to cortisol ratio.

Partially SupportedOvereating saturated fat or carbohydrates is the primary problem leading to health issues like storage of hepatic triglycerides.

Partially SupportedAdding carbohydrates back to a diet after ketogenic or prolonged fasting can lead to an exaggerated blood sugar response for up to 72 hours.

Partially SupportedConsistently practicing intermittent fasting every other day may reduce basal metabolic rate by shrinking calorie allotment.

Partially SupportedWomen on low-carbohydrate diets may fail gestational diabetes tests due to the body's muscle-level refusal of carbohydrates, a phenomenon that can also occur after fasting for approximately 16 hours.

Partially SupportedChecking morning free testosterone to cortisol ratio is a metric to assess overuse of hormetic stressors.

Partially SupportedIntermittent fasting should be treated as a stressor and an anomaly, not a constant practice.

Partially SupportedFasting should be paused if it leads to elevated cortisol or disrupted sleep.

Partially SupportedWhen following a ketogenic diet, prioritize health results over obsessively tracking ketone levels.

Partially SupportedOvereating is the fundamental problem, regardless of the specific macronutrient or micronutrient involved.

Partially SupportedThe speaker finds incorporating more carbohydrates, particularly from fruit, beneficial after moving away from strict ketogenic diets.

Partially SupportedAnimals like deer store fat around organs and behind the eyeballs, which would have been consumed by humans historically.

Partially SupportedPaul Saladino believes dietary modification is the most significant factor humans can use to influence health and disease.

Partially SupportedDaily intermittent fasting may not be necessary for humans, and caloric restriction or protein limitation may not be the primary drivers of longevity.

Partially SupportedEighteen-carbon fatty acids like linoleic acid may disrupt human biochemistry differently than longer-chain fatty acids.

Partially SupportedSome insulin signaling is necessary for normal thyroid hormone levels.

Partially SupportedThe drug rimonabant, an inverse agonist at the CB1 receptor, reduces hunger and aids weight loss but was not approved due to causing suicidal ideation.

Not SupportedA physician's recommendation to eat freely as long as blood sugar stays below an average of 85 with a standard deviation of 10 ignores dietary quality and is problematic.

Partially SupportedEating saturated fat and avoiding seed oils helps achieve insulin resistance in fat cells and insulin sensitivity in muscles.

Partially SupportedSeed oils contribute to insulin resistance by making fat cells metabolically broken.

Partially SupportedExcess omega-3 intake may be linked to depression.

Partially SupportedHunter-gatherer groups may prefer hunting over consuming nuts like mongongo due to their linoleic acid content.

Partially SupportedA diet predominantly animal-based or carnivore that includes muscle meat but excludes organ meat may lead to an imbalance in methionine ratios.

Partially SupportedPaul Saladino feels unwell when consuming a large quantity of egg whites, possibly due to albumin sensitivity or poor egg quality.

Partially SupportedIdeal eggs come from free-ranging chickens consuming a natural diet.

Partially SupportedInsulin signaling is necessary for the liver to produce glutathione.

Partially SupportedAn animal-based diet and Heart and Soil supplements led to new hair growth and cleared acne.

Partially SupportedAn animal-based diet focusing on meat, organs, fruit, and honey is effective for satiety and hunger control.

Partially SupportedA declining free testosterone to cortisol ratio indicates overtraining and can be caused by life stress, lack of sleep, poor nutrition, insufficient sun exposure, or excessive ketogenic dieting.

Not SupportedPostprandial blood glucose response alone is not a sufficient metric for metabolic health.

Partially SupportedLonger-chain fatty acids, such as EPA and DHA, appear beneficial for humans and are metabolized differently than 18-carbon fatty acids.

Partially SupportedMaintaining muscle mass, good libido, and good sleep are important metrics for current well-being and should not be sacrificed for unproven longevity promises.

Partially SupportedModerate amounts of omega-3 fatty acids are beneficial, but excessive intake from sources like fish oil can be harmful.