Riboflavin is crucial for methylation reactions, particularly for individuals with MTHFR polymorphisms, and can help a 'broken' MTHFR enzyme function optimally.

“there's been some great stuff from Chris Master John again to have tips to him that have suggested that in people with MTHFR polymorphisms the adequacy of riboflavin is paramount and if there is not enough riboflavin the MTHFR enzyme will not function properly”

“if there is a robust amount of riboflavin probably three to five milligrams a day in the diet that even people with six seven seven polymorphisms Amenti HFR which is generally the single nucleotide polymorphism that has been shown to affect the efficacy of that enzyme more will essentially correct and have normal homocysteine levels”

“there's some pretty compelling evidence that higher doses of riboflavin are even beneficial for people and might be needed for people with MTHFR polymorphisms”

“so riboflavin is the nutrient needed by your antigen or enzyme”

“by giving it a lot more riboflavin there's a higher likelihood that that riboflavin actually is going to bind to that enzyme it's gonna be able to perform and do work”

“there's really been some interesting research recently to show that if I have adequate riboflavin and that is probably three to five milligrams of riboflavin per day that that is the crux that makes my MTHFR enzyme work well or not well”

“and not getting enough riboflavin can impair the function of your MTHFR lead to elevated levels of homocysteine and”

“you probably need two to three milligrams arrival claim in a day to have your MTHFR work normally”

“what's so fascinating about mthfr and the conversion of uh one form of folate into methylfolate is that that enzyme mthfr has an allosteric binding site for riboflavin and that means that if you have enough riboflavin you can take a quote broken mthfr like mine that functions slowly and make it function just as fast as normally”

“even three or five milligrams a day of riboflavin just from food could affect homocysteine and mthfr”

“if you get one or even 1.5 or two milligrams of riboflavin every day in your diet there's some allosteric regulation of that mthfr enzyme and you can normalize your homocysteine”

“there's this polymorphism the mthfr polymorphism methylene tetrahydrofolate reductase polymorphism i have it um there's two there's six seven seven c to t and 1298 i am homozygous for the 677 polymorphism seems like a lot of italians it is a lot of italians and i believe hispanics as well but what you find in the literature is that if you get a slightly supra um the recommended like if you get slightly above the recommendation for riboflavin every day if you get one or even 1.5 or two milligrams of riboflavin every day in your diet there's some allosteric regulation of that mthfr enzyme and you can normalize your homocysteine”

“those people with an mthfr polymorphism so a little gene uh idiosyncrasy it's not technically a mutation but those people with a little bit of mthfr um polymorphism a idiosyncrasy a uniqueness to their mthfr enzyme if if that mthfr enzyme doesn't work as well if you give them a little more riboflavin maybe two to three milligrams a day which is just over the rda then that mthfr enzyme works great”

“MTHFR polymorphisms and lowering homocysteine levels which is an indication that MTHFR is working better uh with increased doses of riboflavin”

“it's probably an alisic thing where the riboflavin affects the MTHFR enzyme and the activity of the MTHFR enzyme in a way that if you're getting enough riboflavin and you're getting enough folate not folic acid right methylfolate or dihydrofolate”

“the thing that lowers MTHFR activity with those polymorphisms is that MTHFR is a riboflavin dependent enzyme which is vitamin b2 and it has a lower affinity for the riboflavin as a cofactor and so you need better riboflavin status to optimize your MTHFR”